右美托咪定用于腹腔镜胆囊切除术中临床观察分析.docVIP

右美托咪定用于腹腔镜胆囊切除术中临床观察分析 　　[摘要] 目的 分析右美托咪定用于腹腔镜胆囊切除术中的临床效果。 方法 收集2012年1月―2013年12月该院收治的80例腹腔镜胆囊切除术患者临床资料，随机分为对照组与观察组，各40例。对照组气管插管后术前10 min 给予静脉泵注生理盐水，观察组气管插管后术前10 min 给予静脉泵注右美托咪定，均以丙泊酚维持麻醉，对比两组患者临床应用效果。结果 与入室时对比，观察组患者HR、DBP、SBP 在切皮及拔管对比，差异不明显，对照组SBP、DBP明显升高， HR明显增快，差异有统计学意义（P0.05）。观察组患者丙泊酚维持用量明显少于对照组，拔管时间短于对照组，术后躁动发生率低于对照组，差异有统计学意义（P0.05）。结论 于腹腔镜胆囊切除术中应用右美托咪定，具有明显的安全性与有效性，维持稳定的血流动力学，患者术后苏醒迅速，值得临床推广。 　　[关键词] 右美托咪定；腹腔镜胆囊切除术；临床观察 　　[中图分类号] R657.4 [文献标识码] A [文章编号] 1674-0742（2015）01（c）-0126-02 　　[Abstract] Objective analysis of dexmedetomidine for laparoscopic cholecystectomy in the clinical effect of surgery. Methods from 2012 to 2013December， 01 months in our hospital 80 cases of laparoscopic cholecystectomy in patients with clinical data， were randomly divided into control group and observation group， 40 cases in each. The control groupafter intubation preoperatively to 10 min intravenous pump infusion of saline，the observation group after intubation preoperatively to 10 m in intravenouspump infusion of dexmedetomidine， propofol maintained anesthesia with，compared two groups of patients with clinical application effect. Results compared with baseline， the patients in observation group were H R， D B P， SB P in the skin incision and extubation comparison， the difference is not obvious， the control group S B P， D B P was significantly increased， H Rsignificantly increased （P0.05）. Patients in the observation group propofoldosage was less than the control group， the extubation time was shorter than the control group， the postoperative agitation rate lower than that of the control group （P0.05）. Conclusion in laparoscopic cholecystectomyapplications of dexmedetomidine in operation， with safety and effectiveness of the obvious， maintain the stability of hemodynamics， patients quickly regained consciousness after the surgery， is worth the clinical promotion. 　　[Key words] Dexmedetomidine； laparoscopic cholecystectomy； clinical observation 　　右美托咪定作为α2-肾上腺素能受体激动药，其镇静、镇痛、抗交