参七脉心通胶囊对颈动脉硬化患者 血清NO及ET影响.docVIP

参七脉心通胶囊对颈动脉硬化患者 血清NO及ET影响 　　 　　 摘要:目的观察参七脉心通胶囊对颈动脉硬化并高脂血症患者的血脂、血清一氧化氮(NO)、血浆内皮素(ET)水平的影响，进一步探讨参七脉心通胶囊抗动脉粥样硬化的机制。方法将70例高脂血症并颈动脉硬化患者随机分为参七脉心通胶囊中药组（中药组）及阿托伐他汀西药组（西药组），每组35例，分别给予参七脉心通胶囊及阿托伐他汀口服治疗12周。于清晨空腹抽取服药前、服药后及停药2周后的静脉血，检测血总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、NO、ET水平。结果治疗12周后两组患者TC、TG、LDL及ET明显降低，血清NO及HDL水平明显升高，与治疗前相比显差异有统计学意义（P0.05)；而ET水平则明显回升，甚至高于服药前水平（P0.05）。在中药组却未出现这种趋势。结论参七脉心通胶囊对高脂血症并颈动脉硬化患者的血管内皮功能有明显保护作用，从而防治动脉硬化的进一步发展。 　　关键词：颈动粥样脉硬化；高脂血症；阿托伐他汀；血管内皮功能 　　 中图分类号：R543.4R256.2文献标识码：Adoi:10.3969/j.issn2014.06.005文章编号2014 　　 　　Effect of Shenqi Maixintong Capsule on Serum NO and ET in Patients with Carotid Artery Atherosclerosis 　　Hu Jianfang,Chen Chaojun,Yu Zhihui,et al 　　 Department of Neurology,Guangzhou Hospital of Integrated Chinese and Western Medicine (Guangzhou 510800) 　　Abstract:Objective To observe the effect of Shenqi Maixintong capsule (SMC) on the lipid,serum nitric oxide (NO),and plasma endothelin (ET).MethodsSeventy patients with carotid atherosclerosis and hyperlipidemia were randomly divided into two groups:Chinese medicine group (n=35) treated by SMC,and the western medicine group (n=35) treated by atorvastatin orally for 12 weeks.The fasting venous blood was collected before and after treatment,2 weeks after the drug withdrawal,to test the level of total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL),low density lipoprotein cholesterol (LDL),NO,and ET.ResultsAfter treatment of 12 weeks,the levels of TC,TG,LDL and ET1 in two groups weredecreased significantly,while the level of NO and HDL were increased significantly,there was significant difference compared with before treatment (P0.05).The level of NO was decreased significantly,there was no significantly difference compared with that before treatment (P0.05),and the level of ET was increased and it was higher than that before treatment (P0.05).ConclusionThe SMC had protective effect on vascular endothelial in patients with