地氟醚对乳腺癌患者术中顺式阿曲库铵肌松效应影响.docVIP

地氟醚对乳腺癌患者术中顺式阿曲库铵肌松效应影响 　　[摘要]目的 探讨地氟醚对乳腺癌患者术中顺式阿曲库铵肌松效应的影响，为临床治疗乳腺癌疾病寻求有效的方法。方法 选取我院2016年5月～2017年1月收治的40例ASA 1～2级乳腺癌拟择期行乳腺单纯切除+前哨淋巴结活检术患者作为研究对象，随机分为地氟醚组和七氟醚组，各20例。地氟醚组吸入地氟醚及N2O （100～150 ml/min）、O2（200～250 ml/min），ET O2 3.99～4.39 kPa，30 min时一次静脉注射阿曲库铵0.6 mg/kg（2 ED95）。七氟醚组麻醉诱导后经上肢静脉注射0.15 mg/kg顺式阿曲库铵，比较两组的肌松效应。结果 两组的起效时间、插管时间比较，差异无统计学意义（P0.05）。地氟醚组的无反应时间、阻滞维持时间、Tadb 25%恢复时间、T1 75%恢复时间、TOF 70%恢复时间、恢复指数显著长于七氟醚组，差异有统计学意义（P0.05）。两组诱导后的平均动脉压、血氧饱和度、心率水平比较，差异有统计学意义（P0.05）。结论 地氟醚可延长顺式阿曲?祜Ъ∷傻幕指词奔洌?麻醉时间越长，顺式阿曲库铵药量使用越低，提示地氟醚对顺式阿曲库铵肌松效应有增强作用，值得临床推广和完善。 　　[关键词]地氟醚；七氟醚；顺式阿曲库铵；肌松效应；乳腺癌 　　[中图分类号] R737.9 [文献标识码] A [文章编号] 1674-4721（2017）05（a）-0127-04 　　[Abstract]Objective To explore the influence of Desflurane on the muscle relaxation effect of cisatracurium in patients with breast cancer so as to seek effective methods for clinical treatment of breast cancer patients.Methods Altogether 40 ASA 1 or ASA 2 breast cancer patients undergoing simple mastectomy plus sentinel lymph node biopsy in our hospital from May 2016 to January 2017 were selected and randomly divided into the Desflurane group and the Sevoflurane group，20 cases in each group.The Desflurane group was inhaled with Desflurane.N2O （100-150 ml/min），O2 （200-250 ml/min），ET O2 （3.99-4.39 kPa） and intravenously injected with 0 6 mg/kg Atracurium （2 ED95） at 30 min.The Sevoflurane group was intravenously injected with 0.15 mg/kg Cisatracurium via upper extremity after anesthesia induction.The muscle relaxation effect of the two groups were compared.Results There was no significant difference between the two groups in onset time and intubation time （P0.05）.The time of no reaction，maintain time of block， T1 25% recovery time，T1 75% recovery time，TOF 70% recovery time and recovery index of the Desflurane group was longer than that of the Sevoflurane group，with significant difference （P0.05）.While，There was significant difference in the mean arterial blood pressure，oxygen saturation and heart rate at post-induction between the