多西他赛联合奈达铂治疗晚期食管癌临床分析.docVIP

多西他赛联合奈达铂治疗晚期食管癌临床分析 　　[摘要]目的 观察多西他赛联合奈达铂一线治疗晚期食管癌的疗效和不良反应。方法 选取2013年3月～2015年11月我院收治的54例晚期食管癌患者，随机分为两组，每组27例。治疗组给予多西他赛联合奈达铂治疗，对照组给予多西他赛联合顺铂治疗。治疗2个周期后评价疗效，观察不良反应。结果 治疗组和对照组患者的有效率分别为55.56%和48.15%，疾病控制率分别为85.19%和81.48%，两组比较差异均无统计学意义（P0.05）。不良反应主要为呕吐、白细胞减少、血小板减少、肾功能异常，治疗组不良反应程度较对照组明显减轻（P0.05）。结论 多西他赛联合奈达铂治疗晚期食管癌与多西他赛联合顺铂比较，疗效相当，不良反应轻，患者耐受性好。 　　[关键词]奈达铂；多西他赛；晚期食管癌；化学治疗 　　[中图分类号] R735.1 [文献标识码] A [文章编号] 1674-4721（2016）11（c）-0098-03 　　[Abstract]Objective To observe the curative effect and adverse reaction of Docetaxel combined with Nedaplatin in treatment of advanced esophageal cancer.Methods Fifty-four patients with advanced esophageal from March 2013 to November 2015 were randomly divided into two groups.The patients in treatment group were given Docetaxel combined with Nedaplatin，and the patients in control group were given Docetaxel with Cisplatin.The curative effect was evaluated after the end of two cycles of treatment and the adverse reaction was observed.Results The effective rate in the treatment group was 55.56%，and the control group was 48.15%.The disease control rate in the treatment group was 85.19%，and the control group was 81.48%，there was no statistically significant differences in effective rate and disease control rate between two groups （P0.05）.The adverse reactions were maily vomiting，leucopenia，thrombocytopenia，kidney dysfunction，and the degree of adverse reactions of them in the treatment group was lower than that of the control group（P0.05）.Conclusion Compared with the Docetaxel and Cisplatin，the treatment of advanced esophageal cancer with Docetaxel and Nedaplatin has a similar curative effect，few adverse reactions and good tolerance of patients. 　　[Key words]Nedaplatin；Docetaxel；Advanced esophageal cancer；Chemotherapy 　　食管癌是我国常见的恶性肿瘤之一，其发病率和死亡率很高。临床上确诊时大多数病例已属中晚期，不仅局部病灶广泛，出现淋巴结转移，并可能已有远处播散[1]。尸检临床上认为局部晚期的食管癌也有50%以上的病例会发生远处转移[2]。不能治愈的晚期食管癌患者，姑息性联合化疗成为主要的治疗方法。本研究观察我院肿瘤内科采用多西他赛联合奈达铂治疗的晚期食管癌患者的近期疗效和不良反应，并与采用多西他赛联合顺铂治疗的患者比较，现总结报道如下。 　　1资料与方法