复方地龙胶囊对急性脑梗死患者血IL6IL8IL10及TNFα水平影响.docVIP

复方地龙胶囊对急性脑梗死患者血IL6IL8IL10及TNFα水平影响 　　[摘要] 目的：观察急性脑梗死患者应用复方地龙胶囊对血清IL-6、IL-8、IL-10及TNF-α的影响。方法：将80例急性脑梗死患者随机分为治疗组（复方地龙胶囊+常规治疗）和对照组（常规治疗），于治疗前和治疗后10 d检测血清IL-6、IL-8、IL-10及TNF-α水平，并对治疗前、后的数据进行比较。结果：两组急性脑梗死患者血清IL-6[治疗组和对照组分别为（75.62±3.02） pg/ml，（73.95±4.31） pg/ml]、IL-8[治疗组和对照组分别为(1.58±0.21) ng/ml，（1.61±0.33） ng/ml]、IL-10[治疗组和对照组分别为（53.69±5.63） pg/ml，（57.34±4.34） pg/ml]及TNF-α[治疗组和对照组分别（3.65±0.62） pg/ml，（3.83±0.74） pg/ml]水平在治疗前均高于正常组，差异有统计学意义（P＜0.05）；而两组间比较差异无统计学意义（P＞0.05）。治疗后两组患者血清IL-6[治疗组和对照组分别为（25.78±5.35） pg/ml，（38.49±5.25） pg/ml]、IL-8[治疗组和对照组分别为（0.78±0.25） ng/ml，（1.31±0.24） ng/ml]、IL-10[治疗组和对照组分别为（5.78±4.85） pg/ml，（16.76±5.57） pg/ml]及TNF-α[治疗组和对照组分别为（1.45±0.35） pg/ml，（2.65±0.56） pg/ml]水平均下降，治疗组均下降明显，与对照组相比差异有统计学意义（P＜0.05）。结论：监测血清IL-6、IL-8、IL-10及TNF-α水平有助于判断脑梗死的预后；应用复方地龙胶囊治疗可以显著降低患者血清IL-6、IL-8、IL-10及TNF-α水平，从而减轻脑组织损伤，有利于脑梗死患者的转归。 　　[关键词] 脑梗死；复方地龙胶囊；IL-6；IL-8；IL-10；TNF-α 　　[中图分类号] R969[文献标识码]A[文章编号]1673-7210（2011）03（c）-031-03 　　 　　Effects of Lumbricus Capsule on IL-6, IL-8, IL-10 and TNF-α in patients with acute cerebral infarction 　　ZHAO Xiangsheng, ZHENG Dingrong 　　Bao′an District Xixiang People′s Hospital of Shenzhen City, Shenzhen 518102, China 　　[Abstract] Objective: To observe the effects of Lumbricus Capsule on expression of serum IL-6, IL-8, IL-10 and TNF-α levels in acute cerebral infarction patients. Methods: 80 cases of acute cerebral infarction patients were randomly divided into the treatment group (Lumbricus Capsule+routine therapy) and the control group (conventional therapy), before and after the treatment 10 d serum IL-6, IL-8, IL-10 and TNF-α levels were detected, the data was compared before and after the treatment. Results: Two groups in treatment of acute cerebral infarction patients serum IL-6 [the treatment group and the control group respectively was (75.62±3.02) pg/ml, (73.95±4.31) pg/ml], IL-8 [the treatment group and the control group respectively was (1.58±0.21) ng/ml, (1.61±0.33) ng/ml], IL-10 [the treatment group and the control grou