妊娠期肝内胆汁淤积症临床诊治分析.docVIP

妊娠期肝内胆汁淤积症临床诊治分析 　　【摘要】目的 探讨妊娠期肝内胆汁淤积症（ICP）对患者的危害与影响，分析临床治疗效果。方法 将我院2008年4月-2009年7月实施分娩的378例ICP孕妇，其中进行治疗的84例妊娠期肝内胆汁淤积症患者归为观察组，另294例归为对照组，作回顾性分析，比较两组在胎儿早产、窘迫、围产儿发病率方面的差别。结果 观察组在早产率、胎儿窒息窘迫率、围产儿发病率和剖宫产率等方面的机率均明显高于对照组，具有显著性差异（P0.05）。结论妊娠期肝内胆汁淤积症对胎儿和孕妇的危害都很严重。及时诊断和治疗能够避免发生流产和保护孕妇的生命，提高分娩成功率。 　　【关键词】妊娠期 肝内胆汁淤积症 瘙痒 黄疸 临床诊治 　　中图分类号：R714.255文献标识码：A文章编号：1005-0515（2010）11-09-02 　　Intrahepatic cholestasis of pregnancy Clinical Diagnosis and Treatment 　　YANG-MeiXing 　　(Meilong Haifeng County, Shanwei City, Guangdong Province Peoples Hospital, Shanwei, Guangdong 516477) 　　【Abstract】 Objective To investigate the intrahepatic cholestasis of pregnancy (ICP) and the impact of harm to patients, analysis of clinical results. Methods A hospital in April 2008 -2009 implemented in July ICP 378 cases of pregnant women giving birth, which treatment of 84 patients with intrahepatic cholestasis of pregnancy were classified as the observation group, and the other 294 cases classified as the control group, retrospective analysis and comparison of two groups of preterm delivery in fetal, distress, perinatal morbidity differences. Results The group rate of preterm birth, fetal distress rate of asphyxia and perinatal morbidity and cesarean section rate and so the chances are significantly higher, with significant differences (P 0.05). Conclusion intrahepatic cholestasis of pregnancy and pregnant women, harm to the fetus are serious. Timely diagnosis and treatment to pregnant women avoid abortions and protect the lives and improve the delivery success rate. 　　【Key words】pregnancy intrahepatic cholestasis itching jaundiceclinical diagnosis and treatment 　　 　　妊娠期肝内胆汁淤积症是一种多发于妊娠中晚期、对孕妇和胎儿均有严重影响的妊娠并发症。本文选取我院2008年4月-2009年7月实施分娩的378例孕妇以及其中诊断并进行治疗的84例妊娠期肝内胆汁淤积症患者作回顾性分析报告如下： 　　1 材料与方法 　　1.1病例选择 选取我院2008年4月-2009年7月实施分娩的378 ICP例孕妇进行观察。其中84例归为观察组，年龄21―30岁，平均年龄25.4岁；体重46-76kg，平均体重57.6kg。294例归为对照组，年龄23-33岁，平均年龄26.8岁；体重42-83kg，平均体重59.3kg。所有参与回顾的患者均排除病毒性肝炎、胆和胰腺疾病、心脏病、肺病和代谢紊乱症。两组孕妇资料比较，差异无统计学意义。（P0.05