小剂量按时口服他达拉非联合苁蓉益肾颗粒治疗肾阳虚型ED临床观察.docVIP

小剂量按时口服他达拉非联合苁蓉益肾颗粒治疗肾阳虚型ED临床观察 　　【摘要】目的：探讨小剂量按时口服他达拉非联合苁蓉益肾颗粒治疗肾阳虚型ED（Erectile Dysfunction）的临床疗效。方法：选取80例中医辨证属肾阳虚的ED患者，随机分为治疗组和对照组，每组各40例。对照组单纯口服他达拉非，治疗组在口服他达拉非的基础上加用苁蓉益肾颗粒，两组均用药治疗3个月。分别对治疗前后的国际勃起功能指数（IIEF-5）评分、插入阴道成功率、完成性交成功率、总有效率进行统计学分析。结果：治疗组和对照组在IIEF-5评分、插入阴道成功率、完成性交成功率、总有效率方面均较治疗前增加，差异具有统计学意义（P0.05），但治疗组治疗后上述各指标均显著高于对照组治疗后，差异具有统计学意义（P0.05）。结论：小剂量按时口服他达拉非联合苁蓉益肾颗粒治疗肾阳虚型ED效果显著。 　　【关键词】勃起功能障碍；肾阳虚；他达拉非；苁蓉益肾颗粒 　　【Abstract】Objectives： To explore the clinical effect of low dose tadalafil combined with Congrong Yishen granule in the treatment of kidney-yang deficiency type erectile dysfunction （ED）. Methods： 80 ED patients with TCM syndrome of kidney-yang deficiency were randomly divided into treatment group and control group， with 40 cases in each group. The control group was treated with oral tadalafil and the treatment group was treated with oral tadalafil and Congrong Yishen granule. After 3 months treatment， before and after the treatment， the IIEF-5 score， success rate of vagina-inserting， sexual intercourse success rate and total efficiency rate of the two groups were analyzed. Results： The IIEF-5 score， success rate of vagina-inserting， sexual intercourse success rate and total efficiency rate of the two groups were increased compared with these before the treatment， with statistically significant difference （P0.05）， but after treatment， all of the above indicators of the treatment group were significantly higher than those of the control group， with statistically significant difference （P0.05）. Conclusion： The clinical effect of low dose tadalafil combined with Congrong Yishen granule in the treatment of kidney-yang deficiency type ED is remarkable. 　　【Key words】Erectile dysfunction （ED）； Kidney-yang deficiency； Tadalafil； Congrong yishen granular 　　【中图分类号】R697【文献标志码】A 　　勃起功能障碍（erectile dysfunction ， ED）是指不能达到和（或）维持足够的勃起完成满意的性交[1]，祖国医学称之为“阳痿”，是临床上发病率最高的男科疾病之一。国外的一项流行病学调查研究显示随着年龄的增长，ED的发病率也呈上升趋势[2]。国内学者[3]对1162名中老年男性ED流行病学调查显示：中老年男性总发病率为41.8%，40～49岁为21.1