小剂量氟哌噻吨美利曲辛治疗伴有睡眠障碍女性功能性消化不良患者疗效观察.docVIP

小剂量氟哌噻吨美利曲辛治疗伴有睡眠障碍女性功能性消化不良患者疗效观察 　　[摘要] 目的 探讨应用小剂量神经递质调节药物氟哌噻吨美利曲辛治疗伴有睡眠障碍的女性功能性消化不良患者的疗效。 方法 纳入年龄50～65岁之间女性功能性消化不良病例43例，在治疗前、治疗2周、治疗4周时评估患者的胃肠道症状与情绪障碍症状。统计学分析采用卡方检验。 结果 患者胃肠道症状在治疗2周后有32例（74.4%）得到改善（进步14例，有效18例），治疗4周后38例（88.4%）得到改善（进步6例，有效32例）；治疗2周与治疗4周比较，差异有统计学意义（χ2=6.68，P0.05）。治疗4周后，43例睡眠障碍患者有36例较治疗前得到改善（P0.01）；有业余爱好或社交兴趣减低的37例患者28例得到改善；患者叙述临床症状多且乱的34例患者有23例得到改善。未观察到不良反应。观察病例中有5例患者治疗4周仍然无效。 结论 小剂量氟哌噻吨美利曲辛治疗伴有睡眠障碍的女性功能性消化不良患者安全有效。 　　[关键词] 功能性消化不良；女性；睡眠障碍；氟哌噻吨美利曲辛 　　[中图分类号] R57 [文献标识码] B [文章编号] 1673-9701（2017）35-0035-04 　　[Abstract] Objective To investigate the curative effect of low-dose neurotransmitter-modulating drug flupenthixol- melitracen on functional dyspepsia female patients with sleep disturbance. Methods 43 cases of female functional dyspepsia aged 50-65 years were included in the study. Gastrointestinal symptoms and mood disorders of patients were evaluated before treatment， at 2 weeks and 4 weeks after treatment. The chi-square test was used for statistical analysis. Results The symptoms of gastrointestinal tract were improved in 32 patients（74.4%） after 2 weeks of treatment（improvement in 14 cases and effective in 18 cases）， and 38 cases（88.4%） improved after 4 weeks of treatment（improvement in 6 cases， effective in 32 cases）. The data after 2 weeks of treatment and 4 weeks of treatment were compared， and the difference had clear statistical significance（χ2=6.68， P0.05）. After 4 weeks of treatment， 36 of 43 patients with sleep disorders improved compared with those before treatment（P0.01）. 28 of 37 patients with hobby or social interest reduction got improved. 23 of the 34 patients who reported clinically significant and messy symptoms improved. No adverse reactions were observed. Five observed cases were still ineffective after treatment for 4 weeks. Conclusion Small dose flupentixol-melitracin is safe and effective in the treatment of functional dyspepsia in women with sleep disorders. 　　[Key words] Functional dyspepsia； Female； Sleep disord