尖锐湿疣反复发作危险因素探索.docVIP

尖锐湿疣反复发作危险因素探索 　　【第一作者简介】孙月(1981-)，男，主治医师，主要从事皮肤性病临床诊治与研究工作。 　　【摘要】目的:研究尖锐湿疣(CA)患者复发存在的危险因素，同时探讨合理的预防措施。方法:回顾分析我院自2010年5月至2012年10月以来，于我科治疗的276例CA患者临床资料，统计一般情况与个人行为，以及皮损情况和复发情况，对CA复发存在的危险因素进行归纳总结，并依据治疗方式将患者分为两组，对比临床效果。结果:嗜酒（95%CI值为1??319~2??004，OR值为1??658）、熬夜（95%CI值为1??715~21??658，OR值为6??336）、皮损出现于肛周（95%CI值为0??608~1??049，OR值为0??752）、患者皮损的HPV型别呈16型（95%CI值为1??031~2??524，OR值为1??428）、患者皮损的HPV型呈复合型（95%CI值为2??058~6??082，OR值为3??539），均为CA复发最主要的促进因素。经治疗后，患者疣体经激光烧灼，均结痂脱落，达到临床治愈，并且创面能够自行恢复，未出现瘢痕，A组患者再次复发率同B组相比较，差异显著（P＜0??05）。结论:影响CA复发的危险因素较多，患者应用激光、干扰素与斯奇康联合治疗，能够有效降低复发率，应予推广。 　　【关键词】干预对策；复发；危险因素；尖锐湿疣 　　Risk factors of recurrent condyloma acuminatum and preventive measuresSUN Yue, HU Xiuwei, WANG Min, ZHOU Leigui. Department of Dermatology and Venereology, Xinle Municipal Hospital, Shijiazhuang 050700, China 　　【Abstract】Objectives: To study the risk factors for patients with recurrent condyloma acuminatum (CA) and to explore the reasonable precautions. Methods: The clinical data of 276 patients with recurrent CA from May 2010 to October 2012 in our hospital were retrospectively analyzed to study general condition and individual behavior, skin lesions and recurrence. The risk factors for recurrence of CA were summarized. The patients were divided into 3 groups to compare the clinical effect. Results: Alcohol (95% CI=1??319-2??004, OR=1??658), staying up late (95% CI=1??715-21??658, OR=6??336), lesions around anus (95% CI=0??608-1??049, OR=0??752), patients with lesions of HPV type 16 (95% CI=1??031-2??524, OR=1??428), compound skin lesions of HPV type (95%CI=2??058-6??082, OR=3??539) were the main factors causing CA recurrence. After treatment, difference in recurrence rate between group A and B was of significant difference (P 0.05). Conclusion: There are many risk factors effecting CA recurrence. Combined treatment of laser, interferon and BCG-PSN can effectively reduce the recurrence rate, which should be popularized. 　　【Key words】Intervention strategies; Recurrence; R