尿NGAL与妊高症肾损伤相关分析.docVIP

尿NGAL与妊高症肾损伤相关分析 　　[摘要] 目的 探?尿中性粒细胞明胶酶相关脂质运载蛋白（NGAL）水平与妊娠期高血压肾损伤疾病病情进展的关系。方法 选择我院2014年9月～2016年4月间住院治疗并分娩的妊娠期高血压患者60例为观察组（妊娠期高血压患者27例，轻度子痫前期患者15例，重度子痫前期患者6例，子痫期患者12例）；选择60例妊娠期健康孕妇为对照组。分别检测患者入院24h内和产后72h的尿NGAL、血肌酐（Cr）及血清胱抑素C（Cys-C）水平，分析其与妊娠期高血压肾损伤疾病的严重程度及临床表现的关系。结果 入院24h各组尿NGAL、血Cr含量均高于产后72h，Cys-C水平低于产后72h，差异具有统计学意义（P0.05）；除妊娠期高血压组和轻度子痫前期组，各亚组间尿NGAL、血Cr含量差异均有统计学意义（P0.05）；Cys-C含量妊娠期高血压组、轻度子痫前期组以及子痫期组之间差异均有统计学意义（P0.05）；尿NGAL与妊娠期高血压肾损伤的严重程度呈正相关。结论 检测尿NGAL水平可以早发现、早诊断、早治疗妊娠期高血压肾损害，对于临床决策、母婴健康及治疗子痫相关并发症的发生有重要意义。 　　[关键词] 中性粒细胞明胶酶相关脂质运载蛋白；妊娠；高血压；肾损伤 　　[中图分类号] R692； R714.2 [文献标识码] A [文章编号] 2095-0616（2017）07-119-04 　　Correlation analysis of urinary NGAL and renal injury in patients with pregnancy induced hypertension 　　HUANG Guanglian PU Rong WANG Boqin 　　Clinical Laboratory， Dongguan Third Peoples Hospital， Dongguan 523326， China 　　[Abstract] Objective To explore the relationship of urinary neutrophil gelatinase associated lipid carrier protein（NGAL） level and pregnancy induced hypertension renal injury disease progression. Methods 60 cases of pregnancy induced hypertension hospitalized and deliveried in our hospital from September 2014 to April 2016 were selected as the observation group（including 27 cases of pregnancy induced hypertension， 15 cases of mild preeclampsia， 6 cases of severe preeclampsia， and 12 cases of eclampsia）. 60 healthy pregnant women were selected as control group. The levels of urinary NGAL， serum creatinine（Cr） and serum cystatin C（Cys-C） in the patients with 24h and 72h after admission were determined. The relationship between the levels of urinary NGAL， serum creatinine （Cr）， serum cystatin C（Cys-C） and severity of hypertensive disorders in pregnancy， clinical manifestation. Results The urine NGAL and blood Cr levels in the 24h were higher than those in the postpartum 72h. The Cys-C level in the 24h was lower than that of postpartum 72h. And the differences were statistically significant（P 　　[Key words] Neutrophil gelatinase-associated lipoc