急诊应用甲泼尼龙琥珀酸钠联合无创正压通气治疗呼吸衰竭临床研究.docVIP

急诊应用甲泼尼龙琥珀酸钠联合无创正压通气治疗呼吸衰竭临床研究 　　【摘要】 目的：探?应用甲泼尼龙琥珀酸钠联合无创正压通气（Non-invasive positive pressure ventilation，NPPV）治疗呼吸衰竭的临床研究。方法：选取本院2014年1月-2017年2月收治的急性呼吸衰竭患者98例，按照随机数字表法分为观察组与对照组，每组49例。两组均于入院后进行常规治疗，观察组在常规治疗基础上给予甲泼尼龙琥珀酸钠联合NPPV治疗。比较两组治疗前和治疗24 h收缩压、舒张压、心率、血pH、PaO2、PaCO2、呼吸困难改善时间和平均住院时间。结果：治疗24 h，两组收缩压和舒张压比较，差异均无统计学意义（P0.05），观察组心率低于对照组（P0.05）；治疗24 h，两组血pH、PaO2水平均增加，而PaCO2水平降低（P0.05）；治疗24 h，观察组血pH、PaO2水平均高于对照组，而PaCO2水平低于对照组（P0.05）；观察组呼吸困难改善时间和平均住院时间均优于对照组（P0.05）。结论：甲泼尼龙琥珀酸钠联合NPPV治疗呼吸衰竭患者效果显著，具有重要研究意义。 　　【关键词】 甲泼尼龙琥珀酸钠； 无创正压通气； 呼吸衰竭 　　Clinical Study of Methylprednisolone Sodium Succinate Combined with Noninvasive Positive Pressure Ventilation in the Treatment of Respiratory Failure/DENG Shi-zhong，FENG Jian，LIAO Xiao-xing，et al.//Medical Innovation of China，2017，14（26）：105-108 　　【Abstract】 Objective：To explore the application of Methylprednisolone combined with non-invasive positive pressure ventilation（NPPV） in the treatment of respiratory failure.Method：A total of 98 cases of acute respiratory failure in our hospital from January 2014 to February 2017 were selected and divided into the observation group and the control group according to the random number table method，49 cases in each group.Two groups admitted to hospital were given routine treatment，the observation group was given Methylprednisolone Sodium Succinate combined with NPPV treatment on the basis of routine treatment.Systolic blood pressure，diastolic blood pressure，heart rate，blood pH，PaO2，PaCO2，dyspnea improvement time and average length of stay of two groups before treatment and after treatment of 24 h were compared.Result：After treatment of 24 h，there were no statistical significance in systolic and diastolic blood pressure of two groups（P0.05），and heart rate of the observation group was lower than that of the control group（P0.05）.Blood pH，PaO2 levels of two groups increased，and PaCO2 decreased（P0.05）.Blood pH，PaO2 levels of the observation group were higher than those of the control group，and PaCO2 le