托吡酯治疗儿童多发性抽动症效果研究.docVIP

托吡酯治疗儿童多发性抽动症效果研究 　　[摘要] 目的 探讨托吡酯治疗儿童多发性抽动症的临床效果。 方法 选择2014年2月至2015年2月期间我院门诊收治的多发性抽动症儿童患者80例。随机将患儿分为对照组和观察组，每组患儿40例，观察组患儿给予托吡酯，对照组患儿给予硫必利，根据患儿抽动情况对治疗效果进行评价，观察患儿治疗效果及药物不良反应，调整用药剂量。 结果 观察组患儿经过治疗后总有效率为85.0%，对照组患儿为82.5%，差异无统计学意义（P0.05）。观察组患者的不良反应率低于对照组，差异有统计学意义（P0.05）。 结论 采用托吡酯治疗儿童多发性抽动症的临床效果明显，不良反应相对较少，患儿的依从性较好，值得在临床中广泛推广。 　　[关键词] 托吡酯；儿童多发性抽动症；临床效果 　　[中图分类号] R749.94 [文献标识码] A [文章编号] 1674-4721（2016）04（b）-0066-03 　　[Abstract] Objective To discuss the clinical effect of topiramate in treatment of tourette syndrome （TS）. Methods 80 children with TS treated in our hospital from February 2014 to February 2015 were selected and randomly divided into observation group and control group，each with 40 cases.Children in the observation group were treated by topiramate，while children in the control group were treated by tiapride.Therapeutic effect was evaluated according to syptoms of children.The dose of administration was adjusted based on therapeutic effect and adverse reaction. Results After treatment，the overall response rate in the observation group was 85.0%，and was 82.5% in the control group，there was no significant difference in overall response rate between two groups （P0.05）.The rates of adverse reaction in the observation group was lower than that in the control group （P0.05）. Conclusion The clinical effect of topiramate in treatment of TS is significant with low incidence of adverse reaction and favorable compliance，thus it is worthy to be promoted. 　　[Key words] Topiramate；Tourette syndrome；Clinical effect 　　儿童多发性抽动症是一种慢性、多发性的神经性精神疾病，临床特征为运动性抽动、发声抽动、强迫行为和情绪障碍等，在10岁以下的儿童多发，成人患病率低于儿童，且男性患者多于女性[1]。对于多发性抽动症的发病原因尚不明确，有专家认为儿童多发性抽动症是一种遗传疾病，也可能与病理、心理、环境、神经递质等有关。大多数儿童多发性抽动症患儿经过治疗后均可缓解症状，1/4以上的患儿抽动症状可明显减轻，临床上可通过西药治疗、行为治疗和心理治疗等多方法对患儿病症进行干预[2]。近些年儿童多发性抽动症的发病率不断提高，给患病的儿童和家长带来烦恼，由于治疗该种疾病较为困难，在发病后如不能及时治疗，对患儿的学习、生活、家庭及社会均会造成严重影响。本次研究采用托吡酯治疗儿童多发性抽动症的临床效果，现报道如下。 　　1 资料与方法 　　1.1 一般资料 　　收集2014年2月～2015年2月期间我院门诊收治的多发性抽动症儿童患者80例均行脑电图、头颅CT、血常规、尿常规、肝功及肾功等常规检查[3-4]。入组标准：符合美国精神保障诊断手册中