慢性心力衰竭患者血浆同型半胱氨酸水平及意义.docVIP

慢性心力衰竭患者血浆同型半胱氨酸水平及意义 　　【摘要】 目的：探讨慢性心力衰竭（CHF）患者血浆同型半胱氨酸（Hcy）的水平及意义。方法：选取200例患者，其中心功能正常患者100例（对照组），CHF患者100例（CHF组）。按照美国纽约心脏病学会（NYHA）心功能分级标准将CHF患者分为Ⅱ、Ⅲ、Ⅳ级组。比较分析非CHF患者及CHF患者Hcy、N端B型脑钠肽前体（NT-proBNP）水平及左室射血分数（LVEF）。结果：CHF组的Hcy水平高于对照组（P0.05），且不同心功能分级（Ⅱ～Ⅳ级）患者之间的Hcy水平比较差异有统计学意义（P0.05）；CHF组的NT-proBNP水平高于对照组（P0.05），且不同心功能分级（Ⅱ～Ⅳ级）患者之间的NT-proBNP水平比较差异有统计学意义（P0.05）；CHF组的LVEF低于对照组（P0.05），且不同心功能分级（Ⅱ～Ⅳ级）患者之间的LVEF比较差异有统计学意义（P0.05）。CHF组血浆Hcy水平与NT-proBNP水平呈正相关（r=0.564，P0.05），与LVEF呈负相关（r=0.455，P0.05）。结论：CHF患者血浆Hcy升高，Hcy水平有可能作为CHF的重要标志物之一。 　　【关键词】 慢性心力衰竭； 同型半胱氨酸； N端B型脑钠肽前体； 左室射血分数 　　【Abstract】 Objective：To observe the concentration and clinical meaning of plasma homocysteine on chronic heart failure patients（CHF）.Method：There were 200 patients， 100 of them do not have CHF （control group），100 of them have CHF（CHF group）.The CHF patients were separated as group Ⅱ，group Ⅲ，group Ⅳ according to the America New York Heart Association （NYHA）.The plasma homocysteine，N-terminal B-type natriuretic peptide （NT-proBNP） and left ventrical eject function（LVEF） were compared on all of the patients.Result：The plasma homocysteine was higher on the group CHF than on the control group（P0.05）.The plasma homocysteine was different from group Ⅱ to group Ⅲ and group Ⅳ（P0.05）.The NT-proBNP was higher on the group CHF than on the control group（P0.05）.The plasma NT-proBNP was different from group Ⅱ to group Ⅲ and group Ⅳ（P0.05）.The LVEF was lower on the group CHF than on the control group（P0.05）.The LVEF was different from group Ⅱ to group Ⅲ and group Ⅳ（P0.05）.The plasma homocysteine was positively correlated with NT-proBNP， and negatively correlated with LVEF on the CHF patients.Conclusion：The plasma homocysteine is higher on the CHF， it may be considered as one of the important CHF markers. 　　【Key words】 Chronic heart failure； Homocysteine； N-terminal B-type natriuretic peptide； Left ventrical eject function 　　慢性心力衰竭（chronic heart failure，CHF）是大多数心血管疾病的终末阶段，其发生和发展有多种机制参与，过程复杂且尚不明确。研究表明，同型半胱氨酸（homocystein