左旋肉碱对慢性腹膜透析患者贫血及肌肉症状影响-effect of l - carnitine on anemia and muscle symptom in patients with chronic peritoneal dialysis.docxVIP

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左旋肉碱对慢性腹膜透析患者贫血及肌肉症状影响-effect of l - carnitine on anemia and muscle symptom in patients with chronic peritoneal dialysis.docx

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左旋肉碱对慢性腹膜透析患者贫血及肌肉症状影响-effect of l - carnitine on anemia and muscle symptom in patients with chronic peritoneal dialysis

河南科技大学硕士学位论文 Results： 1. Plasma FC decreased gradually in accordance with months on dialysis with a significant correlation, r=-0.711, P0.001. Contrast with FC leves, the AC/FC ratio was shown to increase gradually in accordance with months on dialysis, r=0.58, P0.001. Plasma FC levels in patients with muscle symptoms were significantly lower than patients without muscle symptoms, (28.11±3.11) μmol/L vs (36.25±6.47) μmol/L, P0.01, and AC/FC ratio was reverse, patients with muscle symptoms were significantly higher than patients without muscle symptoms, (0.84±0.15) μmol/L vs (0.41±0.20) μmol/L, P0.01. Plasma TC levels of the two groups without statistical significance. (1) Patients treated with L-carnitine demonstrated an improvement in muscular symptoms. The baseline visual analogue scale (VAS) of muscle pain was (23.66±4.96) mm, after 24 weeks supplementation, carnitine group had lesser score than baseline, (19.34±3.46) mm, P0.01. The VAS of muscle weakness was also decreased with L- carnitine therapy, (27.76±7.6) mm vs (21.11±3.60) mm, P0.01. L-carnitine treatment also had positive effects on handgrip strength, (164.34±58.99) N vs (248.55±69.74) N, P0.01. (2) After 24 weeks of L-carnitine treatment, plasma FC, AC, and TC had increased obviously, conversely, AC/FC ratio was reduced significantly compared with baseline. (3) The Hb leves increased from 106.35±7.65 to 116.3±4.93 g/L while the rHuEPO requirement decreased from 148.04±31.67 to 127.50±30.17 U/(kg·week) in carnitine patients after 24 weeks, and the two aspects were unchanged in controls. (4) Before and after L-carnitine treatment, there were no significant differences in each lipid parameter, and no severe adverse effect was reported. Conclusions： Plasma and tissue L-carnitine deficiency were correlated with months on dialysis. L-carnitine supplementation had beneficial effects in such clinical symptoms associated with carnitine deficiency of peritoneal dialysis patients. Our study has show that L-carnit