慢性阻塞性肺疾病急性加重期患者血清α1―AT及CRP检测临床意义.docVIP

慢性阻塞性肺疾病急性加重期患者血清α1―AT及CRP检测临床意义 　　【摘要】 目的：研究血清α1-AT及CRP水平检测在慢性阻塞性肺疾病（COPD）急性加重期患者中的临床意义。方法：将本院收治的64例AECOPD患者随机数字表法分为对照组和观察组，两组患者均给予基础治疗、雾化吸入沙丁胺醇和异丙托溴铵治疗。观察组在对照组治疗基础上，加用布地奈德雾化吸入治疗。治疗7 d后比较血清CRP和α1-AT水平，评定并比较临床疗效。结果：AECOPD组血清CRP显著高于COPD稳定期组（P0.05）。观察组和对照组患者治疗后CRP和α1-AT较治疗前均显著降低（P0.05）。结论：CRP可作为反应COPD病情严重程度的敏感性指标，联合与α1-AT检测，对COPD的诊断和疗效判断具有一定的临床应用价值。 　　【关键词】 α1-AT； CRP； 慢性阻塞性肺疾病 　　【Abstract】 Objective： To observe the clinical effect alpha1-antitrypsin （α1-AT） and serum C reactive protein （CRP） levels in patients with acute exacerbation chronic obstructive pulmonary disease （COPD）. Method： 64 patients with AECOPD in our hospital were chosen and divided randomly to observation group and control group， which all treated by basis treatment and pulverization inhalation treatment with salbutamol and ipratropium bromide. Patients in observation group were also given pulverization inhalation treatment of budesonide. The levels of serum CRP and α1-AT were compared after seven days treatment， and the clinical effects were evaluated and compared. Result： The CRP level of the AECOPD group was significantly higher than that of the stable COPD group （P0.05）. The levels of serum CRP and α1-AT significantly decreased after treatment， and the CRP level was significantly lower in observation group than that in the control group （P0.05）. Conclusion： CRP is a sensitive indicator for the patients with COPD， combing with α1-AT associated detection， have clinical practical value for diagnose and therapeutic effect judging in COPD. 　　【Key words】 α1-AT； CRP； Chronic obstructive pulmonary diseases 　　First-author’s address： People’s Hospital of Tangyin County， Tangyin 456150， China 　　doi：10.3969/j.issn.1674-4985.2015.01.011 　　慢性阻塞性肺疾病（chronic obstructive pulmonary diseases， COPD）是一种重要的慢性呼吸系统疾病，主要表现为呼吸道气流受限[1]。其患病人数多，发病率和死亡率均较高，是目前世界四大致死性疾病之一[2]。其发病机制目前尚未完全明确，普遍认为各种炎症标志物参与COPD的发生发展过程与病情密切相关，并有望成为诊断、评估和治疗的重要辅助指标，寻找检测方法简便、敏感性高、能特异性反映COPD炎症的炎性标志物，是研究的主要方向之一[3]。α1-抗胰蛋白酶（α1-antitrypsin，α1-AT）是