慢性阻塞性肺疾病患者合并骨质疏松对预后影响.docVIP

慢性阻塞性肺疾病患者合并骨质疏松对预后影响 　　[摘要] 目的 探讨慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）患者急性加重频率、症状严重程度、运动耐力与骨密度（bone mineral density，BMD）的关系。 方法 选取北京宣武医院呼吸科就诊的稳定期COPD患者89例，收集患者的一般资料、急性加重频率、呼吸困难评分、COPD评估测试评分（COPD assessment test，CAT）、6 min步行距离（6 minute walk distance，6MWD）；测定患者的肺功能参数及BMD。根据BMD测量结果将COPD患者分为骨量正常组、骨量减低组及骨质疏松组。 结果 三组间急性加重频率、CAT评分、6MWD比较均有统计学意义（P0.05）；腰椎BMD与急性加重频率、CAT评分呈显著负相关（r=-0.228、0.249，P0.05）；股骨颈BMD与6MWD呈显著正相关（r=0.212，P0.05）。 结论 COPD患者急性加重频率越高、CAT评分越低、6MWD越小其骨密度越低，骨密度降低可对COPD患者的预后产生影响。 　　[关键词] 慢性阻塞性肺疾病；骨质疏松；骨密度；预后 　　[中图分类号] R563.9；R589 [文献标识码] B [文章编号] 1673-9701（2015）30-0024-04 　　Influence of concurrent osteoporosis on prognosis of patients with chronic obstructive pulmonary disease 　　ZHU Xiaomei1 NIE Xiuhong1 YANG Jingjing2 　　1.Department of Respiratory Medicine， Xuanwu Hospital of Capital Medical University， Beijing 100053， China； 2.Department of Respiratory Medicine， the Luhe Hospital of Affiliated Capital Medical University， Beijing 101149， China 　　[Abstract] Objective To investigate the relationship between acute exacerbation frequencies， severity of symptoms， exercise tolerance and bone mineral density （BMD） of the patients with chronic obstructive pulmonary disease（COPD）. Methods Eighty-nine patients with stable COPD treated in Department of Respiratory Medicine，Xuanwu Hospital of Capital Medical University were selected and their general information， acute exacerbation frequencies， dyspnea scores， COPD assessment test scores（CAT） and 6 minute walk distance （6MWD） were collected； The patients lung function parameters and BMD were measured. Based on the BMD measurement results， the COPD patients were divided into the normal bone mass group， the reduced bone mass group and the osteoporosis group. Results The differences in acute exacerbation frequencies，CAT scores and 6MWD among the three groups were statistically significant（P0.05）； The lumbar vertebral BMD was in significantly negative correlation to the acute exacerbation frequency and