抗CCP抗体检测及RF定量对RA诊断特异性和敏感度分析.docVIP

抗CCP抗体检测及RF定量对RA诊断特异性和敏感度分析 　　[摘要] 目的 探究分析抗环瓜氨酸肽（CCP）抗体检测及类风湿因子（RF）定量检测对类风湿关节炎（RA）的诊断特异性和敏感度，以期为类风湿关节炎的临床早期诊断提供借鉴价值。方法 随机选取吉林省公安边防总队医院2015年5月―2017年5月期间收治的57例类风湿关节炎患者以及55例非类风湿性自身免疫性疾病患者作为研究对象，同期选择到院进行健康体检的健康者55名作为对照组，采用ELISA法检测各组患者血清抗CCP抗体，同时采用免疫比浊法检测RA，对比分析各组抗CCP与RA检测结果差异。结果 RA组患者血清抗CCP抗体检测阳性率（87.72%）明显高于非RA组（9.09%）和对照组（0.00%），RA组患者血清RF检测阳性率（80.70%）显著高于非RA组（30.90%）和对照组（7.27%），血清抗CCP抗体联合血清RF检测的敏感度为72.35%，血清抗CCP抗体联合血清RF检测的特异度98.05%明显高于其他两组检测方案，组间比较差异有统计学意义（P0.05）。结论 抗CCP抗体与RF联合检测能够提高RA诊断率，具有较高的灵敏度和特异度，值得临床推广应用。 　　[关键词] 抗CCP抗体；RF；类风湿关节炎 　　[中图分类号] R593 [文献标识码] A [文章编号] 1674-0742（2017）09（b）-0182-03 　　[Abstract] Objective This paper tries to explore the anti cyclic citrullinated peptide （CCP） antibody and rheumatoid factor （RF） quantitative detection of rheumatoid arthritis （RA） diagnostic sensitivity and specificity， so as to provide reference for the clinical value of early diagnosis of rheumatoid arthritis. Methods 57 cases of rheumatoid arthritis patients treated from May 2015 to May 2017 in this hospital and 55 cases of non rheumatoid autoimmune disease patients were selected as the research objects， and 55 cases of health examination during the same period in the hospital were selected as the control group， the serum anti CCP antibody was detected by ELISA method， at the same time RA was detected by immune turbidity method， the anti-CCP and RA were compared between the groups. Results The positive rate of serum anti-CCP antibody in RA group was 87.72%， significantly higher than that in non RA group of 9.09% and the control group of 0.00%， the positive rate of serum RF in RA group was 80.70%， significantly higher than that in non RA group of 30.90% and the control group of 7.27%， serum anti CCP antibody combined with serum RF detection sensitivity was 72.35%， serum anti CCP antibody combined detection of serum RF specificity was 98.05%， significantly higher than that of the other two groups of detection scheme， and the difference between groups was statistically