抗HBV―DC联合胸腺肽α1治疗e抗原阴性慢性乙型肝炎初步临床研究.docVIP

抗HBV―DC联合胸腺肽α1治疗e抗原阴性慢性乙型肝炎初步临床研究 　　【摘要】 目的 探讨抗乙肝树突状细胞（HBV-DC）联合胸腺肽α1在e抗原阴性慢性乙型肝炎患者中的临床治疗效果。方法 80例e抗原阴性慢性乙型肝炎患者， 随机分为两组， 每组40例。对照组采用抗HBV-DC治疗， 实验组联合胸腺肽α1治疗， 比较两组治疗效果。结果 实验组总有效率95.0%， 明显高于对照组85.0%， 差异有统计学意义（P0.05）；实验组谷草转氨酶（AST）指标、谷丙转氨酶（ALT）指标， 低于对照组， 差异有统计学意义（P0.05）。结论 e抗原阴性慢性乙型肝炎发病率较高， 临床上采用抗HBV-DC联合胸腺肽α1治疗效果理想， 能够提高临床疗效， 改善患者肝功能， 值得推广。 　　【关键词】 抗乙肝树突状细胞 ；胸腺肽α1；e抗原阴性慢性乙型肝炎；治疗效果 　　DOI：10.14163/j.cnki.11-5547/r.2015.17.025 　　Primary clinical research of anti-HBV-DC combined with thymosin α1 in the treatment of e antigen-negative chronic hepatitis B KE Cheng-neng， LIU Yong， XIAO Hong-gang. The First Department of Internal Medicine， Dongguan Renkang Hospital of Southern Medical University， Dongguan 523952， China 　　【Abstract】 Objective To investigate the clinical effect of anti- hepatitis B dendritic cell （HBV-DC） combined with thymosin α1 in the treatment of e antigen-negative chronic hepatitis B. Methods A total of 80 patients with e antigen-negative chronic hepatitis B were randomly divided into two groups， with 40 cases in each group. Control group received anti-HBV-DC for treatment， and experimental group received anti-HBV-DC combined with thymosin α1 for treatment. Curative effects of the two groups were compared. Results The experimental group had total effective rate as 95.0%， which was much higher than 85.0% of the control group， and their difference had statistical significance （P0.05）. The experimental group had lower levels of aspartate aminotransferase （AST） index and alanine aminotransferase （ALT） index than the control group， and their difference had statistical significance （P0.05）. Conclusion The morbidity of e antigen-negative chronic hepatitis B is high. Clinical treatment by anti-HBV-DC combined with thymosin α1 provides ideal effect in improving clinical effect and liver function. This method is worthy of promotion. 　　【Key words】 Anti-hepatitis B dendritic cell； Thymosin α1； e antigen-negative chronic hepatitis B； Curative effect 　　慢性乙型肝炎是临床上常