支气管扩张患者经长期低剂量罗红霉素治疗临床观察.docVIP

支气管扩张患者经长期低剂量罗红霉素治疗临床观察 　　【摘 要】目的：分析支气管扩张患者经长期低剂量罗红霉素治疗的临床疗效。方法：??88例支气管扩张患者根据随机设计分组法分为两组各44例，对照组口服盐酸氨溴索，治疗组口服盐酸氨溴索，结合长期低剂量罗红霉素治疗。结果：治疗组总有效率88.6%高于对照组总有效率63.6%，治疗后呼吸困难评分、肺部病变评分及排痰量均低于对照组，数据差异有统计学意义（P0.05）；两组患者用药期间未出现明显不良反应，肝肾功能正常。结论：对支气管扩张患者采取长期低剂量罗红霉素治疗，临床效果显著。 　　【关键词】支气管扩张；长期；低剂量罗红霉素 　　Clinical observation of long-term low-dose roxithromycin in patients with bronchiectasis 　　Abstract Objective： To analyze the clinical efficacy of long-term low-dose roxithromycin in patients with bronchiectasis. Methods： Eighty-eight patients with bronchiectasis were divided into two groups according to the random design method. 44 patients in the control group were treated with ambroxol hydrochloride. The treatment group was treated with ambroxol hydrochloride combined with long-term low-dose roxithromycin. Results： The total effective rate was 88.6% in the treatment group and 63.6% in the control group. The dyspnea score， lung lesion score and sputum volume after treatment were all lower than those in the control group. The difference was statistically significant （P0.05）. No obvious adverse reactions occurred in the two groups of patients during the medication， and the liver and kidney functions were normal. Conclusion： Long-term low-dose roxithromycin in patients with bronchiectasis has significant clinical effects. 　　Key words： Bronchiectasis； Long-term； Low-dose roxithromycin 　　【中图分类号】R562 【文献标识码】A 【文章编号】1672-3783（2018）05-03-0-01 　　支气管扩张是目前危害人们身心健康、生活质量的常见慢性呼吸道疾病，患者反复感染会加重患者肺功能损害。因此临床治疗支气管扩张时，需减轻患者支气管慢性炎症，减少支气管扩张急性发作次数，缓解患者病症，进而改善患者肺部功能。抗生素是治疗支气管扩张常用药物，患者长期反复抗生素应用，会致细菌耐药性，进而影响患者治疗效果。目前对支气管扩张临床治疗，需采取抗炎、免疫调节、抗氧化等治疗方案。本文对支气管扩张患者采取长期低剂量罗红霉素治疗，其结果分析如下。 　　1 资料与方法 　　1.1 一般资料 　　选取2017年1月至2018年1月期间我院收治的支气管扩张患者88例作为研究对象，经临床症状、体征、肺部CT、实验室指标等检查，与世界卫生组织[1]中支气管扩张诊断标准相符合；排除心肝肾功能异常、急性发作期支气管扩张、药物过敏症患者；患者知情本次研究，签署了研究同意书；医院伦理会对本次研究审核通过；根据随机设计分组法分为两组，对照组44例，男患者28例，女16例；年龄35-70（46.7±8.2）岁；病程5-20年，平均（11.6±2.4）年；治疗组44例，男患者26例，女18例；年龄35-72（47.1±8.0）岁；病程5-20年，平均（12.0±2.8）年；两组患者基线资料在以统计学软件处