新辅助化疗联合放疗治疗中晚期食管癌临床分析.docVIP

新辅助化疗联合放疗治疗中晚期食管癌临床分析 　　作者单位：617023 四川省攀枝花钢铁（集团）公司职工总医院? 　　通讯作者：胡朝阳 　　【摘要】 目的 探讨奥沙利铂与氟尿嘧啶在中晚期食管癌新辅助化疗中的应用价值。方法 将2007年3月~2010年9月于本院诊断为中晚期食管癌的52名患者随机分为试验组和对照组，试验组术前予以奥沙利铂、氟尿嘧啶联合化疗，局部放疗，术后继续予以原化疗方案治疗。对照组术前不予以新辅助化疗，仅予以局部放疗，术后予以上述化疗方案治疗。随访两组患者，观察两组患者疗效差异。结果 试验组近期疗效、肿瘤局控率、生存率均显著高于对照组（P0.05），肿瘤远处转移率显著低于对照组（P0.05），试验组新辅助化疗期间并未出现严重不良反应。结论 奥沙利铂联合氟尿嘧啶在中晚期食管癌新辅助化疗治疗中具有较强的肿瘤抑制作用，对改善此类患者的预后具有积极意义。? 　　【关键词】 中晚期食管癌； 新辅助化疗； 奥沙利铂； 氟尿嘧啶； 局部放疗?? 　　Clinical analysis of new adjuvant chemotherapy combined with radiotherapy for advanced esophageal carcinoma HU Chao-yang.The Employees Genneral Hospital of Panzhihua iron and steel （Group） Company,Panzhihua 617023,China? 　　【Abstract】 Objective To discuss the value of neoadjuvant chemotherapy of oxaliplatin combined with fluorouracil in treatment of late-mid esophageal cancer patients.Methods A total of 52 cases of late-mid esophageal cancer patients diagnosed in our hospital between Mar, 2007 and Sep, 2010 were randomly divided into experimental group or control group. Patients in experimental group were given preoperative chemotherapy of oxaliplatin combined with fluorouracil and local radiochemotherapy followed by surgery and postoperative chemotherapy. Patients in control group only received local radiochemotherapy, surgery and postoperative chemotherapy. The efficiency in all patients were observed and analyzed in follow-up visit.Results Short-term efficiency, remission rate of tumor and survival rate in experimental group were significantly higher than that of control group（P0.05）; Transfer rate of tumor was lower than that of control group（P0.05）; No severe side effects were found in all patients.Conclusion Neoadjuvant chemotherapy of oxaliplatin combined with fluorouracil has a better efficiency in inhibiting tumor growth, resulting in a better prognosis.? 　　【Key words】 Late-mid esophageal cancer； Neoadjuvant chemotherapy； Oxaliplatin； Fluorouracil； Local radiochemotherapy? 　　doi：10.3969/j.issn.1674-4985.2012.02.004 　　食管癌是我国常