氮卓斯汀鼻喷剂联合地氯雷他定治疗过敏性鼻炎随机对照研究.docVIP

氮卓斯汀鼻喷剂联合地氯雷他定治疗过敏性鼻炎随机对照研究 　　【摘要】 目的：探讨氮卓斯汀鼻喷剂联合地氯雷他定治疗过敏性鼻炎的临床疗效和安全性。方法：选取2012年 　　1月-2014年9月本院收治的174例过敏性鼻炎患者作为研究对象，采用随机数字表法将所选患者分为研究组和对照组，每组各87例。对照组患者使用氮卓斯汀鼻喷剂治疗，研究组患者在对照组基础上使用地氯雷他定治疗。综合比较两组患者治疗总有效率、治疗前后各证候积分及不良反应发生率的差异。结果：研究组患者治疗总有效率为93.1%，高于对照组的80.5%，两组比较差异有统计学意义（P0.05），研究组治疗后各项证候积分均优于对照组，两组比较差异有统计学意义（P0.05）。结论：氮卓斯汀鼻喷剂联合地氯雷他定治疗过敏性鼻炎效果确切，对过敏性鼻炎相关症状有显著疗效，且不良反应少，值得临床推广使用。 　　【关键词】 氮卓斯汀鼻喷剂； 地氯雷他定； 过敏性鼻炎； 临床疗效 　　【Abstract】 Objective：To investigate the effects and safety of azelastine nasal spray combined with desloratadine for the treatment of allergic rhinitis.Method：174 cases of allergic rhinitis in our hospital were selected from January 2012 to September 2014 and were randomly divided into research group and control group，87 cases in each group.The control group was treated with azelastine nasal spray，the research group was treated with azelastine nasal spray combined with desloratadine.The total effective rate，symptom scores before and after treatment and adverse reactions rate were compared.Result：The total effective rate of research group was 93.1%，which was higher than 80.5% of control group，the difference was statistically significant（P0.05）；after treatment，the symptom scores of research group was better than control group，the difference was statistically significant （P0.05）.Conclusion：Azelastine nasal spray combined with desloratadine in the treatment of allergic rhinitis has exact effect.It can effectively relieve clinical symptoms without serious adverse reactions.It’s worthy of clinical widely used. 　　【Key words】 Azelastine nasal spray； Desloratadine； Allergic rhinitis； Clinical efficacy 　　First-author’s address：The Fifth Affiliated Hospital of Southern Medical University，Guangzhou 510900，China 　　doi：10.3969/j.issn.1674-4985.2015.21.001 　　过敏性鼻炎即变应性鼻炎，是指特应性个体接触变应原后，主要由IgE介导的介质（主要是组胺）释放，并有多种免疫活性细胞和细胞因子等参与的鼻黏膜非感染性炎性疾病[1]。其发生的必要条件有3个：特异性抗原即引起机体免疫反应的物质；特应性个体即所谓个体差异、过敏体质；特异性抗原与特应型个体两者相遇[2-3]。过敏性鼻炎的临床症状有喷嚏、清水样涕、鼻塞、鼻痒等，过敏性鼻炎伴发疾病可分为相同的致病途径（如变态反应）或合并其他疾病（黏