氨溴索对新生儿肺炎炎症介质及肺血流指标影响研究.docVIP

氨溴索对新生儿肺炎炎症介质及肺血流指标影响研究 　　【摘要】 目的：分析氨溴索治??新生儿肺炎对患儿炎性介质因子及肺血流指标的影响，旨在为临床诊断及治疗新生儿肺炎的方法提供科学参考。方法：回顾选取本院接诊的新生儿肺炎病例62例，依据用药方案的不同分为两组，常规治疗组30例，实施常规对症治疗；联合治疗组32例，基于常规治疗组，加用氨溴索治疗。比较两组治疗2周后炎症介质指标hs-CRP、TNF-α，IFN-γ、IL-2、IL-6、IL-10与肺血流动力学指标PVR、mPAP、PAWP的表达变化。结果：治疗后，联合治疗组炎性应激因子hs-CRP（2.26±0.81）pg/mL、IFN-γ（24.26±4.19）pg/mL表达均较常规治疗组明显下降，而TNF-α（37.49±6.22）pg/mL表达较常规治疗组明显上升，两组比较差异均有统计学意义（P0.05）。治疗后，联合治疗组其他炎性因子IL-2（3.21±0.83）pg/mL、IL-6（79.16±11.59）pg/mL、IL-10（4.46±2.28）pg/mL表达均比常规治疗组显著下降，两组比较差异均有统计学意义（P0.05）。治疗后，联合治疗组肺血流动力学指标mPAP（23.21±10.83） mm Hg、PAWP（8.82±2.84） mm Hg与PVR（1.46±0.76） mm Hg表达水平显著低于常规治疗组，两组比较差异均有统计学意义（P0.05）。结论：盐酸氨溴索注射液应用于新生儿肺炎中可显著改善患儿肺血流动力学和血清炎性因子的表达水平，有较好的治疗意义。 　　【关键词】 氨溴索； 新生儿肺炎； 炎症介质； 肺血流指标 　　【Abstract】 Objective：To analyze the effects of Ambroxol on neonatal pneumonia in children with inflammatory mediators and pulmonary blood flow，to provide scientific reference for clinical diagnosis and treatment of neonatal pneumonia.Method：62 cases of neonatal pneumonia admitted in our hospital were retrospectively selected.According to the different treatment regimen，they were divided into two groups.30 patients were in the conventional treatment group， they were treated with conventional symptomatic therapy.The combined treatment group of 32 cases，they were taken with Ambroxol treatment based on conventional treatment.The changes of the expression levels of inflammatory mediators hs-CRP，TNF-α，IFN-γ，IL-2，IL-6，IL-10 and pulmonary hemodynamic parameters PVR， mPAP， PAWP of two groups were compared after treatment 2 weeks.Result：After treatment，the expression of inflammatory factors hs-CRP （2.26 ± 0.81） pg/mL and IFN-γ （24.26±4.19） pg/mL in combination treatment group were significantly lower than those in conventional treatment group， while the expression of TNF-α （37.49±6.22） pg/mL in combination treatment group was significantly higher than that of the conventional treatment group，the differences were statistically significant（P 　　【Key words】 Ambroxol； Neonatal pneumon