滋肾健脾化瘀汤治疗糖尿病视网膜病变疗效及对患者血糖C肽和胱抑素C水平影响.docVIP

滋肾健脾化瘀汤治疗糖尿病视网膜病变疗效及对患者血糖C肽和胱抑素C水平影响 　　[摘要] 目的 探究滋?I健脾化瘀汤治疗糖尿病视网膜病变（DR）疗效及对患者血糖、C肽（CP）和胱抑素C（Cys-C）水平的影响。 方法 方便选取2016年1―12月间泉州市妇幼保健院眼科收治的84例DR患者，采用随机数字表法分为观察组和对照组，每组42例。2组均予以常规西药治疗，观察组加用滋肾健脾化瘀汤治疗。比较2组疗效，评估治疗前后患者血糖波动水平[平均血糖水平（MBG）、平均血糖波动幅度（MAGE）、日间血糖平均绝对差（MODD）]，及CP、Cys-C指标水平。 结果 ①治疗3个月后，观察组临床疗效（92.86%）较对照组（76.19%）更优（χ2=4.459，P=0.035）。②治疗3个月后，2组血糖波动指标[MBG（t=8.779、P=0.000，t=6.913、P=0.000）、MAGE（t=8.424、P=0.000，t=4.333、P=0.000）、MODD（t=7.498、P=0.000，t=4.846、P=0.000）]和Cys-C（t=12.782、P=0.000，t=7.058、P=0.000）水平均低于治疗前，且观察组降幅大于对照组（t=4.549、P=0.000，t=4.439、P=0.000，t=4.098、P=0.000，t=3.177、P=0.002）；2组CP水平均较治疗前上升（t=9.109、P=0.000，t=4.263、P=0.000），观察组增幅大于对照组（t=3.596、P=0.001）。 结论 滋肾健脾化瘀汤辅助治疗DR有利于可使Cys-C降低、CP升高，能更好地控制血糖波动，疗效显著。 　　[关键词] 滋肾健脾化瘀汤；糖尿病视网膜病变；血糖；C肽；胱抑素C 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2017）12（c）-0019-03 　　[Abstract] Objective This paper tries to investigate the curative effect of Zishen Jianpi Huayu decoction on diabetic retinopathy （DR） and its effect on the level of blood sugar， C-peptide and Cys-C in patients. Methods Convenient selected 84 DR patients from January to December 2016 in this hospital were randomly divided into observation group and control group， with 42 cases in each group. Both groups were treated with conventional Western medicine， and the study group was treated with Yishen Jianpi Huayu soup. The efficacy of the two groups was compared. The level of blood glucose fluctuation [blood glucose level （MBG）， average blood glucose fluctuation range （MAGE）， daily blood glucose absolute mean difference （MODD）]， and CP and Cys-C index levels were evaluated before and after treatment. Results ①after the treatment for three months， the clinical curative effect of observation group was 92.86%， higher than the control group of 76.19%（χ2=4.459， P=0.035）.②after the treatment for three months， the blood glucose fluctuation index [MBG（t=8.779， P=0.000， t=6.913， P=0.000）， MAGE （t=8.424， P=0.000， t=4.333， P=0.000）， MODD （t=7.498， P=0.000， t=4.846， P=0.000）] and