游泳运动对慢性支气管炎大鼠肺组织MDA和SOD影响.docVIP

游泳运动对慢性支气管炎大鼠肺组织MDA和SOD影响 　　【摘要】 目的：探讨有氧运动对慢性支气管炎大鼠肺组织MDA含量和SOD活性的影响。方法：将SD大鼠30只按照随机数字表法分为正常组、模型组和运动模型组，每组10只。采用改良烟熏法建立慢性支气管炎大鼠模型，并对慢性支气管炎模型大鼠进行8周游泳运动干预，检测运动干预后各组大鼠肺组织MDA和SOD含量变化。结果：与正常组相比，慢性支气管炎模型组大鼠体重显著降低（P0.05），运动模型组体重降低不明显。慢性支气管炎模型组大鼠肺组织和支气管肺泡灌洗液（BALF）中MDA含量明显高于正常对照组和运动模型组（P0.05）。同时慢性支气管炎模型组大鼠肺组织和支气管肺泡灌洗液（BALF）中SOD含量显著低于正常对照组和运动模型组（P0.05）。结论：8周游泳运动明显提高了慢性支气管炎大鼠肺组织SOD活性，降低了MDA含量，提高了大鼠抗氧化损伤能力，减轻了炎症反应，改善了肺功能。 　　【关键词】 慢性支气管炎； 肺组织； 游泳运动 　　【Abstract】 Objective：To investigate the effects of swimming on MDA and SOD of lung tissue in chronic bronchitis rats.Method：Thirty SD rats were randomly divided into three groups：the normal group，the model group and the exercise-model group，10 rats in each group.Modified smoked method was used to establish the rat chronic bronchitis model.The rats of chronic bronchitis were trained for 8 weeks in swimming pools.Changes of MDA and SOD level in lung tissue of rats in each group were detected after exercise intervention.Result：Compared with the normal control group，body weight of rats in chronic bronchitis group decreased significantly（P0.05），but the weight loss was not obvious in exercise group.The MDA of lung tissue and bronchial alveolar lavage fluid （BALF） in chronic bronchitis rats were significantly higher than that of normal control group and exercise group（P0.05）.At the same time，the SOD of lung tissue and BALF in chronic bronchitis group was significantly lower than that in the normal control group and exercise group（P0.05）.Conclusion：8-week swimming exercise can increase the SOD activity and reduce the MDA in lung tissue of chronic bronchitis rats，which increase the ability of antioxidant injury，relieve the inflammation，improve lung function. 　　【Key words】 Chronic bronchitis； Lung tissue； Swimming 　　First-author’s address：Tianmen Hospital of Traditional Chinese Medicine，Tianmen 431700，China 　　doi：10.3969/j.issn.1674-4985.2014.25.017 　　慢性支气管炎是常见的呼吸系统疾病，在中老年人中发病率较高，且病程长、反复发作，不仅严重危害患者个人身体健康，同时还对患者生活造成一定的负担，降低患者生活质量。慢性支气管