瑞舒伐他汀联合氯吡格雷治疗不稳定型心绞痛临床疗效观察.docVIP

瑞舒伐他汀联合氯吡格雷治疗不稳定型心绞痛临床疗效观察 　　[摘要] 目的 观察瑞舒伐他汀联合氯吡格雷治疗不稳定型心绞痛的临床疗效。 方法 选取我院2013年1月～2014年12月收治的不稳定型心绞痛患者100例，根据治疗方法不同随机分成对照组和观察组，每组各50例，对照组予常规治疗，观察组加用瑞舒伐他汀、氯吡格雷，连用2周；比较两组的疗效及血脂情况。 结果 治疗后观察组无效2例，治疗后的总有效率为96.00%；对照组无效15例，治疗后的总有效率为70.00%，观察组的总有效率显著高于对照组（P0.05）。治疗后观察组的心绞痛发作持续时间显著短于对照组（P0.05）。治疗后观察组患者的血脂水平TC、TG及LDL-C、HDL-C水平分别较治疗前及对照组明显改善（P0.05）。 结论 瑞舒伐他汀联合氯吡格雷治疗不稳定型心绞痛疗效确切，除了可降低血脂，还可改善心肌缺血和减少心绞痛发作，值得推广和应用。 　　[关键词] 不稳定型心绞痛；瑞舒伐他汀；氯吡格雷；血脂 　　[中图分类号] R541.4 [文献标识码] B [文章编号] 1673-9701（2016）07-0084-03 　　[Abstract] Objective To observe the clinical efficacy of rosuvastatin combined with clopidogrel in treatment of unstable angina pectoris. Methods A total of 100 cases patients with unstable angina pectoris patients in our hospital from January 2013 to December 2014 were selected and randomly divided into control group and observation group， each group of 50 cases， the control group received routine treatment， while the observation group was treated with rosuvastatin， clopidogrel，for 2 weeks. The curative effect and blood lipid of the two groups were compared. Results After treatment， ineffective of the observation group was 2 cases， the total efficiency was 96.00%； in the control group， ineffective was 15 cases， the total efficiency was 70.00%， the total efficiency of the observation group was significantly higher than that of the control group（P0.05）. After treatment， the duration of angina pectoris attack of observation group was significantly shorter than that in the control group（P0.05）. After treatment， lipid levels of TC， TG and LDL-C， HDL-C were improved significantly respectively than that before treatment and the control group（P0.05）. Conclusion The curative effect rosuvastatin cutting atorvastatin combined with clopidogrel in treatment of unstable angina pectoris is exact， in addition to lower blood lipids can also improve myocardial ischemia and reduce the attack of angina pectoris， it is worth popularization and application. 　　[Key words] Unstable angina pectoris