神经节苷脂联合高压氧舱治疗新生儿缺血性脑病疗效观察.docVIP

神经节苷脂联合高压氧舱治疗新生儿缺血性脑病疗效观察 　　【摘要】 目的 探讨单唾液酸四己糖神经节苷脂联合高压氧舱治疗新生儿缺血性脑病的临床疗效。方法 选取2008年1月至2010年12月我院住院治疗的新生儿缺血性脑病患儿56例，随机分为治疗组28例，对照组28例，两组均采用常规治疗，治疗组在常规治疗的基础上采用单唾液酸四己糖神经节苷脂钠联合高压氧舱治疗，比较两组患儿的临床疗效。结果 两组患儿临床疗效比较，治疗组显著优于对照组，(P0.05)；两组患儿NBNA评分比较，两组患儿治疗后评分均显著高于治疗前，(P0.05)；治疗后评分治疗组显著高于对照组，(P0.05)，差异具有统计学意义。结论 单唾液酸四己糖神经节苷脂钠联合高压氧舱治疗新生儿缺血性脑病，具有疗效确切，不良反应少的优势，值得临床推广应用。? 　　【关键词】 　　神经节苷脂；高压氧舱；新生儿缺血性脑病；疗效 　　?? 　　【Abstract】 ObjectiveTo investigate the single-sugar ganglioside sialic acid IV and hyperbaric chamber has been the treatment of neonatal ischemic encephalopathy patients. Methodsfrom January 2008 to December 2010 our hospital?s neonatal ischemic encephalopathy in 56 cases, 28 were randomly divided into treatment group and control group leach for 28 cases.Patients in both groups were treated with conventional treatment group In the conventional treatment on the basis of a single sialic acid ganglioside hexose Sodium four hyperbaric oxygen therapy, the clinical efficacy of two groups were compared. ResultsComparison of clinical efficacy in children, the treatment group was significantly better than the control group, (P0.05); NBNA score in the two groups of children, two groups of children score after treatment was significantly higher than before treatment, (P0.05).Treatment scores were significantly higher in treatment group, P0.05, with statistical significance. Conclusion The four-hexose ganglioside sialic acid sodium and hyperbaric oxygen chamber treatment of neonatal ischemic encephalopathy, with effective, the advantage of fewer adverse reactions, is worthy of clinical application.? 　　【Key words】 　　Ganglioside; Hyperbaric chamber；Ischemic encephalopathy in neonates；Effect 　　 　　新生儿缺氧缺血性脑病(HIE)是指在围产期窒息而致脑的缺血缺氧性损害损伤，是新生儿期的常见病、多发病，可引起脑瘫、癫痫、智力低下听觉和视觉障碍等临床后遗症，严重影响新生儿生存质量，死亡率极高［1］。目前对于新生儿缺氧缺血性脑病尚无特效疗法，我院采用单唾液酸四己糖神经节苷脂联合高压氧舱治疗新生儿缺血性脑病，取得了显著疗效，现报告如下。? 　　1 资料与方法? 　　1.1 一般资料 　　选取2008年1月至2010年12月我院住院治疗的新生儿缺血性脑病患儿56例，男31例，女25例；胎龄37~42周，平均40周；体重2.5~4 kg，平均3.25 kg；其中重度患儿18例，