老年2型糖尿病采取米格列醇和阿卡波糖分别联合二甲双胍治疗效果比较研究.docVIP

老年2型糖尿病采取米格列醇和阿卡波糖分别联合二甲双胍治疗效果比较研究 　　[摘要] 目的 探讨老年2型糖尿病采取米格列醇和阿卡波糖分别联合二甲双胍治疗的效果比较研究。 方法 将2016年5月―2017年5月在该院老年内分泌科治疗的80例老年2型糖尿病患者随机分为两组，对照组采用阿卡波糖分别联合二甲双胍治疗，观察组采用米格列醇联合二甲双胍治疗，比较两组患者的临床疗效、血糖及胰岛素水平变化、不良反应。结果 观察组治疗有效率为82.50%，略高于对照组的80.00%，差异无统计学意义（P0.05）；观察组治疗后FBG、2 hPG、HbA1c、FINS明显低于对照组，差异有统计学意义（P0.05）；观察组恶心、腹泻、肠鸣音增加、排气增多等不良反应明显少于对照组（P0.05）。 结论 老年2型糖尿病采取米格列醇联合二甲双胍治疗效果显著，能有效控制血糖，增加胰岛素敏感性，且不良反应轻微，具有积极的临床意义。 　　[关键词] 老年2型糖尿病；米格列醇；阿卡波糖；二甲双胍；治疗效果 　　[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2017）10（b）-0061-02 　　[Abstract] Objective To study the comparison of effect of migltol combined with melbine and acarbose combined with melbine in treatment of senile patients with type 2 diabetes. Methods 80 cases of senile patients with type 2 diabetes admitted and treated in our hospital from May 2016 to May 2017 were selected and randomly divided into two groups， the control group were treated with acarbose combined with melbine， while the observation group were treated with migltol combined with melbine， and the clinical curative effect， blood glucose and changes of insulin level were compared between the two groups. Results The treatment effective rate in the observation group was slightly higher than that in the control group， （82.50% vs 80.00%）， and the differences were not statistically significant（P0.05）， after treatment， the FBG， 2 hPG， HbA1c， FINS were obviously lower than those in the control group， and the differences were statistically significant（P0.05）， and the nausea， diarrhea， increase of bowel sound and exhaust increase in the observation group were obviously lower than those in the control group（P0.05）. Conclusion The effect of migltol combined with melbine in treatment of senile patients with type 2 diabetes is obvious， which can effectively control the blood glucose， increase the sensitivity of insulin with mild adverse reactions， and it is of positive significance. 　　[Key words] Senile patients with type 2 diabetes； Migltol； Acarbose； Melbine； Treatment effect