羧甲基纤维素钠眼液治疗白内障术后干眼疗效分析.docVIP

羧甲基纤维素钠眼液治疗白内障术后干眼疗效分析 　　摘要：目的分析羧甲基纤维素钠眼液对白内障超声乳化摘除术后干眼的治疗效果。方法选取2013年12月~2014年2月于我院行白内障超声乳化摘除术的年龄相关性白内障患者106例（129眼），随机分为对照组和治疗组，其中治疗组加用羧甲基纤维素钠眼液。对患者分别行术前及术后1 d、1 w、1个月泪膜破裂时间(BUT) 、角膜荧光染色(FL)检查、和自觉症状评分。结果白内障术后干眼主观症状增加、BUT明显缩短、FL明显增多。至术后1个月，对照组干眼主观症状、BUT与术前相比仍具有统计学意义（P＜0.05）。治疗组术后1 w干眼主观症状、BUT和FL已接近术前水平（P＞0.05），且术后各时间点较对照组干眼主观症状更轻、BUT更长、FL更少（P＜0.05）。结论白内障超声乳化手术后早期使用羧甲基纤维素钠眼液可有效改善干眼症状、恢复泪膜稳定性，缩短眼表功能修复时间。 　　关键词：羧甲基纤维素钠眼液；白内障术后；干眼 　　Use of Carboxymethylcellulose Sodium Eye Drops in the Management of Dry Eyes after Phacoemulsification 　　WAN Wen-juan 　　(Department of Ophthalmology, First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing 400016, China) 　　Abstract：ObjectiveTo investigate the effect of carboxymethylcellulose sodium eye drops on the age-related cataract patients with dry eye after phacoemulsification.MethodsA total of 106 patients underwent operation (129 eyes) with age-related cataract referred to our hospital from December 2013 to February 2014 were enrolled in the study. Patients were randomly divided the treatment group and control group. The treatment group was received carboxymethylcellulose sodium eye drops therapy. Tear break-up time, cornea fluorescein staining were measured, as well as subjective symptoms were graded before and 1d, 1w, 1m after phacoemulsification and intraocular lens implantation.ResultsThe subjective symptoms were worse, tear break-up time was shorter, and cornea fluorescein staining on epithelium was more commonly seen post-operation as compare to pre-operation. The subjective symptoms grade and tear break-up time were still abnormal in the control group 1m post-operation (P0.05) , and all the post-opertation index were better in the treatment group than that in control group (P0.05). ConclusionThe carboxymethylcellulose sodium eye drops could efficiently relieve the symptoms of dry eye and maintain the tear film stable for the patients underw