舒利迭联合无创通气救治老年COPD伴呼吸衰竭临床研究.docVIP

舒利迭联合无创通气救治老年COPD伴呼吸衰竭临床研究 　　[摘要]目的 研究舒利迭?合无创通气救治老年慢性阻塞性肺疾病（COPD）伴呼吸衰竭患者的临床疗效。方法 选取2014年1月～2015年11月我院40例老年COPD伴呼吸衰竭患者，抽签随机分为观察组与对照组，每组20例，给予对照组患者无创通气治疗，观察组患者应用舒利迭联合无创通气治疗，比较两组治疗前后呼吸频率（RR）、心率（HR）、呼吸流量峰值（PEF）水平变化，比较两组治疗前后血氧分压（PaO2）、动脉血二氧化碳分压（PaCO2）、氢离子浓度指数（pH）等血气指标、第1秒用力呼气量（FEV1）、用力肺活量（FVC）等肺功能指标水平变化情况。结果 观察组患者治疗后RR、HR水平较对照组显著降低（P0.05）。治疗后观察组PaO2、pH水平较对照组显著升高（P0.05）；观察组PaCO2水平较对照组显著降低（P0.05）。观察组治疗后FEV1/FVC水平较对照组显著升高（P0.05）。结论 舒利迭联合无创通气治疗老年COPD伴呼吸衰竭患者效果显著，可使患者的呼吸、心率逐渐恢复正常，动脉血气水平得到有效改善，肺功能得到提高，可见其治疗方式值得临床推广应用。 　　[关键词]舒利迭；无创通气；慢性阻塞性肺疾病；呼吸衰竭 　　[中图分类号] R563.9 [文献标识码] A [文章编号] 1674-4721（2017）02（a）-0026-03 　　[Abstract]Objective To study the clinical effects of Seretide combined with noninvasive ventilation in treating chronic obstructive pulmonary disease （COPD） with respiratory failure in the elderly.Methods 40 elderly COPD patients with respiratory failure in our hospital from January 2014 to November 2015 were selected and divided into observation group and control group according to random draw，and each group was 20 cases.Patients in the control group were given noninvasive ventilation，and patients in the observation group were given Seretide combined with noninvasive ventilation.The respiratory rate （RR），heart rate （HR） and change level of peak expiratory flow rate （PEF） in two groups were compared.Before and after treatment，the blood gas indexes liked partial pressure of blood oxygen （PaO2），arterial carbon dioxide partial pressure （PaCO2），hydrogen ion concentration index （pH），the change of lung function index liked forced expiratory volume in one second （FEV1），forced vital capacity （FVC） in two groups were compared.Results After treatment，RR and HR in the observation group was obvious lower than that in the control group （P0.05）.After treatment，the level of PaO2，pH in the observation group obvious increased than that in the control group （P0.05）；the level of PaCO2 in the observation group was decreased obviously than that in the control group （P0.05）.After treatme