舒利迭联合苦参碱雾化吸入治疗儿童支气管哮喘疗效分析.docVIP

舒利迭联合苦参碱雾化吸入治疗儿童支气管哮喘疗效分析 　　【摘要】 目的 观察舒利迭联合苦参碱雾化吸入治疗儿童支气管哮喘的疗效及其对Th1/Th2免疫平衡的调节作用。 方法 90例支气管哮喘急性发作患儿， 随机分为对照组和观察组。对照组接受舒利迭治疗， 观察组采用舒利迭联合苦参碱雾化吸入治疗。治疗7 d后， 观察两组患儿临床疗效、呼吸指标的变化， 检测血清干扰素-γ（INF-γ）与白细胞介素-4（IL-4）水平。结果 两组患儿总体有效率分别为91.0%与95.0%， 差异无统计学意义（P0.05）， 但与对照组相比， 观察组显效例数较多， 无效例数较少， 差异具有统计学意义（P0.05）。相比对照组， 观察组血氧饱和度（SaO2）、1秒用力呼气容积（FEV1）、FEV1占预计值百分比（FEV1%）等呼吸指标的改善情况较明显， 且INF-γ/IL-4比值增高更明显， 提示观察组对Th1/Th2的平衡调节作用更强。结论 舒利迭联合苦参碱雾化吸入治疗儿童支气管哮喘的疗效较好， 机制可能与联合苦参碱雾化吸入后， 对Th1/Th2免疫的平衡调节作用增强有关。 　　【关键词】 儿童；哮喘；舒利迭；苦参碱；Th1/Th2 　　【Abstract】 Objective To observe the effect of seretide combined with matrine aerosol inhalation in the treating of bronchial asthma in children and reveal the underlying mechanism involved with the balance of Th1/Th2. Methods Divided 90 children with bronchial asthma into control group and observation group， control group was only treated with seretide but observation group was treated with sertide combined with matrine aerosol inhalation. After 7 d of treatment， observed the clinical curative effect， monitored the respiratory parameters and detected the serum level of interferon-γ（INF-γ） and interleukin-4（IL-4） in each group. Results Total effective rate in control group and observation group was 91.0% and 95.0% respectively， differences were not statistically significant（P0.05）. but compared with control group， the observation gorup had more effective cases and less ineffective cases， differences were statistically significance（P0.05）. Compared with control group， the observation group had a higher remarkable effective rate with a lower ineffective rate. Mean while the observation group shown a significant improvement in SaO2， FEV1， FEVI%. All the group could correct the imbalance in Th1/Th2， however the observation group showed a more obvious regulative effect. Conclusion Clinical effect of seretide combined with matrine aerosol inhalation in the treatment of bronchial asthema in children is considerable， the mechanism may be that matrine can better mainta