舒利通颗粒治疗慢性前列腺炎盆腔疼痛综合征临床与实验研究.docVIP

舒利通颗粒治疗慢性前列腺炎盆腔疼痛综合征临床与实验研究 　　【摘 要】 目的:研究舒利通颗粒治疗阴虚湿热夹瘀型慢性前列腺炎的临床疗效，并探讨其机制。方法:用舒利通颗粒治疗80例阴虚湿热夹瘀型慢性前列腺炎3个月，观察临床疗效及治疗前后患者慢性前列腺炎症状评分（NIH-CPSI）变化情况。动物实验研究采用二甲苯、醋酸等致炎剂，观察舒利通颗粒对由此产生的小鼠耳廓肿胀及扭体的镇痛作用、大鼠棉球肉芽肿形成的影响。结果:舒利通颗粒治疗80例阴虚湿热夹瘀型慢性前列腺炎，痊愈14例，显效52例，有效9例，总有效率93.8%。治疗后患者NIH-CPSI评分明显低于治疗前（P0.01）。实验研究：舒利通颗粒对小鼠醋酸扭体反应次数有显著性降低(P0.01)；舒利通颗粒对二甲苯的致炎作用有显著性减轻(P0.05)；舒利通颗粒对大鼠棉球肉芽肿形成有显著的抑制作用(P0.01)。结论:舒利通颗粒对阴虚湿热夹瘀型慢性前列腺炎有较好的治疗效果。 　　【关键词】 慢性前列腺炎； 舒利通颗粒； 抗炎、消肿、镇痛 　　Clinical and laboratory research on the effect of Shulitong granuleson chronic prostatitis and pelvic pain syndrome 　　JIANG Haisheng1, LIU Chunying2, LING Yun1 　　1 Navy General Hospital, Beijing, 100037 China 　　2 The Second Hospital of Shijiazhuang,Hebei, 050051 China 　　【Abstract】 Objectives:To investigate the therapeutic effect of Shulitong granules on chronic prostatitis and to explore its functioning mechanism. Methods: Shulitong granules were applied to 80 patients with chronic prostatitis for 3 months to observe their effects and to compare the NIH-CPSI changes before and after the treatment. As to laboratory research, Shulitong granules were used to ease pain of auricle swelling in mice and to affect the formation of granuloma in rats. The inflammation of animals was caused by such agents as dimethylbenzene and acetic acid. Results: Clinical observation showed that among 80 cases of chronic prostatitis treated with Shulitong, 14 cases recovered, 52 cases improved and 9 cases reacted positively, the overall efficiency rate being 93.8%. NIH-CPSI value after the treatment was significantly lower than that before the treatment(P0.01). Laboratory study indicated that Shulitong granules can significantly lower the frequency of body-twisting response in mice caused by acetic acid (P0.01), can have significant anti-inflammatory effect(P0.05), and can significantly inhibit the formation of granuloma in rats(P0.01). Conclusion: Shulitong granules have satisfactory therapeutic effects on chronic prostatitis. 　　【Key words】 C