苗族人群幽门螺旋杆菌CagA因子与胃癌相关性分析.docVIP

苗族人群幽门螺旋杆菌CagA因子与胃癌相关性分析 　　【摘要】 目的 探讨怀化地区麻阳苗族自治县苗族人群幽门螺杆菌(Hp)感染特别是其细胞色素相关基因(CagA)与胃癌的相关性。方法 收集湖南怀化麻阳苗族自治县人民医院2001~2008年经病理检查确诊的胃癌患者100例,其中苗族52例,汉族48例,苗族患者平均(60.12±12.35)岁,汉族患者平均年龄(67.75±11.64)岁。分别检测两族胃癌患者Hp和Hp CaA基因株的感染率。结果 苗族人群胃癌组Hp的阳性率均显著高于汉族人群胃癌组(P0.05),苗族人群胃癌组HpCagA基因株阳性率均显著高于汉族人群胃癌(P0.05)。结论 Hp CagA基因株感染与胃癌关系密切,苗族人群胃癌患者CagA基因株感染率显著高于汉族胃癌患者组,这是否是苗族人群胃癌发病较早、发病率较高的一种原因尚待进一步研究。 　　【关键词】 胃癌;幽门螺杆菌;苗族 　　 　　Discussion on the relations between Hp CagA and gastric carcinoma in Miao people 　　 　　HUANG Man-xi,ZHANG Lin,TANG Qian-jun,et al.The department of internal medicine, Auto-county Miao of Mayang people`s hospitai,Huaihua 419400,China 　　 　　【Abstract】 Objective To investigate the relations between HP CageA and gastric carcinoma in Auto-county Miao of MayangHuaihua region. Methods 100 patients with gastric carcinoma,among which 52 cases were Miao people. Means age was (60.12±12.35) years and 48 Han people,means age was (67.75±11.64) years. Hpand HpCagA were detected in patients with gastric carcinoma. Results The rate of infection Hp in Miao people with gastric carcinoma group was significantly higher than those Han people group(P0.05). The rate of infection Hp CagA inMiao people with gastric carcinoma group was significantly higher than those Han people group(P0.05). Conclusion There is a significant difference of Hp CageA in gastric carcinoma between Miao people and Han people. The early on set and high incidence rate of gastric carcinoma in Miao people may be due to their high Hp CagA. 　　【Key words】 Gastric carcinoma; Helicobacterpylori; Miao people 　　 　　作者单位:419400湖南省怀化麻阳苗族自治县人民医院内一科(黄满喜 汤千军 陆洪华 谭必春 郑碧梅);长沙市四医院(张林) 　　 　　大量研究资料表明,幽门螺杆菌(Helicobacter pylori, Hp)感染是胃癌发病过程中的重要因素,世界卫生组织已于1994年将Hp感染列为胃癌的一类致癌原。细胞毒素相关抗原A(CagA)是由HP相应的CagA基因编码产生的一种外膜蛋白,是Hp的重要致病因子。本研究通过检测苗族人群Hp相关胃癌患者的血清CagAHp抗体,进一步探讨苗族人群HpCagA与胃癌的相关性,并且CagA致病性可能与种族有关。 　　1 资料与方法 　　1.1 研究对象 来自本院2001~2008年100例接受胃镜检查的患者,按病变性质分为两组。①苗族人群胃癌组:52例,男30例,女22例,平均(60.12±12.35)岁,病理分型为肠型31例,弥散型21例;②汉族人群胃癌组:48例,其