吡格列酮对糖尿病大鼠肾小球足细胞保护及其与抗炎、抗纤维化作用的关系 内科学(内分泌与代谢疾病)专业论文.docxVIP

安徽医科大学硕士学位论文  PAGE 6 4.1 糖尿病肾脏疾病发病机制概述······································· ··············· 41 4.2 DN和足细胞损伤 42 4.3 吡格列酮对糖尿病大鼠肾小球足细胞的保护作用··············· ··············· 43 4.4 吡格列酮保护糖尿病肾小球足细胞的机制························ ··············· 45 4.5 吡格列酮对脂代谢的影响 ············································· ··············· 48 4.6 实验中的经验和不足 ··················································· ··············· 49 5 结论 ·········································································· ··············· 50 参考文献 ······································································· ··············· 51 附录 ············································································· ··············· 59 综述 ············································································· ··············· 62  中英文缩写对照表 缩写 英文名称 中文名称 AGEs advanced glycosylation end products 终末糖基化产物 Alb albumin 白蛋白 AngII angiotensin II 血管紧张素 II AOD average optical density 平均光密度 AT1 angiotensin II type 1 receptor 血管紧张素 II 1 型受体 BM body mass 体重 BSA bovine serum albumin 牛血清白蛋白 BUN CNF blood urea nitrogen congenital nephritic syndrome ofthe Finnish type 尿素氮 芬兰型先天性肾病综 合征 DEPC diethylpyrocarbonate 焦碳酸二乙酯 DM diabetes mellitus 糖尿病 DN diabetic nephropathy 糖尿病肾脏疾病 ECM extracellular matrix 细胞外基质 ELISA ESRD FBG FN enzyme-linked immunosorbent assay end-stage renal disease fasting blood glucose fibronectin 酶联免疫吸附法 终末期肾脏疾病 空腹血糖 纤维连接蛋白 FP foot process 足突 FPFR foot process fusion rate 足突融合率 GAPDH glyceraldehyde phosphate dehydrogenase 磷酸甘油醛脱氢酶 GBM glomerular basement membrane 肾小球基底膜  GBMT GPSD  glomerular basement membrane thickness Glomerular slit diaphragm protein 基底膜厚度 肾小球足细胞裂隙隔 HbA1c glycosylated hemoglobin A1c 糖化血红蛋白 A1c  HDL-C high-density lipoprotein cholesterol 高密度脂蛋白胆固醇 HE hematoxylin-eosin Ig immunoglobulin 苏木精-伊红 免疫球蛋白  IOD integrated optical density 累计光密度 KI kidney hypertrophy index 肾脏肥大指数  LDL