西洋参改善低舒张压老年高血压患者预后临床研究.docVIP

西洋参改善低舒张压老年高血压患者预后临床研究 　　【摘要】目的 观察西洋参联合降压药物治疗低舒张压的老年高血压的临床疗效。方法 选取100名65岁以上的经正规降压治疗后的低舒张压的老年高血压患者，其收缩压150 mmHg、舒张压70 mmHg，随机分为治疗组及对照组各50例，其中治疗组采用西洋参联合降压药物治疗，对照组单纯使用降压药物治疗，评价两组的治疗效果、副作用及再入院情况。结果 治疗组和对照组治疗后的临床症状、血压均有所改善，但治疗组的疗效明显优于对照组（P0.01），其舒张压稳定甚至有所回升，且因心脑血管疾病再住院率较对照组明显下降（P0.01），两组均无明显不良反应。结论 西洋参联合降压药物治疗低舒张压的老年高血压疗效确切，安全性较好，为临床用药提供了一个新选择。 　　【关键词】老年高血压；低舒张压；西洋参 　　【中图分类号】R544.1 【文献标识码】B 　　【Abstract】Objective To observe the clinical efficacy of combination therapy of American Ginseng and antihypertensive drugs to treat elderly hypertensive patients with low diastolic blood pressure. Methods In the study， 100 elderly hypertensive patients after regular antihypertensive therapy with low diastolic blood pressure （systolic blood pressure 150mmHg and diastolic blood pressure 70mmHg）， who were older than 65 years old， were enrolled and randomized into the treatment group and the control group. The patients in the treatment group received combination therapy of American Ginseng and antihypertensive drugs， and the patients in the control group were treated only with antihypertensive drugs. The clinical efficacy， side effects and re-admissions in the two groups were evaluated. Results The two groups both had clinical improvements in symptoms and blood pressures. However， the treatment group showed a greater improvement than control group （P0.01）. The treatment group had a lower re-admission rate than the control group （P0.01）. There were no adverse drug reactions in either group. Conclusions The combination therapy of American Ginseng and antihypertensive drugs was clinically effective and safe to treat elderly hypertensive patients with low diastolic blood pressure. It will provide a new option for clinical medication. 　　【Key word】Elderly hypertension；Low diastolic blood pressure；American Ginseng 　　近年来，老年高血压患者在治疗过程中出现的低舒张压情况越来越引起学术界的重视，舒张压的高低变化与心血管事件呈负相关，血压越低，心血管事件的发生率越高，当舒张压低于70 mmHg时，心血管死亡率明显增加[1]。而目前使用的降压药物在降低收缩压同时往往伴随着舒张压的下降，一些患者往往会因为舒张压过低而引发心绞痛甚至心肌梗塞或缺血性脑卒中[2]，这使