超声对糖尿病合并阵发性房颤患者血管内皮功能评价价值.docVIP

超声对糖尿病合并阵发性房颤患者血管内皮功能评价价值 　　[摘要] 目的 探讨超声对糖尿病合并阵发性房颤患者的血管内皮功能评价价值。 方法 糖尿病合并阵发性房颤患者160例（观察组）与健康志愿者160例（对照组）分别采用彩超评估其肱动脉功能。 结果 与对照组比较，观察组患者肱动脉内径百分变化率明显下降（P 0.05），治疗组的左心房容积比对照组明显增大（P 0.05）。从图像学分析，观察组的基础状态肱动脉内径大于对照组（P 0.05）。 结论 应用彩超技术早期无创评价糖尿病合并阵发性房颤患者血管内皮功能，对于指导临床早期应用改善治疗，降低阵发性房颤致死率，具有广阔的临床应用前景。 　　[关键词] 糖尿病；阵发性房颤；彩超 　　[中图分类号] R445.1 [文献标识码] B [文章编号] 1673-7210（2012）01（c）-0163-02 　　 　　Study on ultrasound in detecting vascular endothelial function of diabetic with paroxysmal atrial fibrillation patients 　　LIU Guangde TAN Huadan WANG Zhongde CHEN Yicai 　　Department of Functional, Zhuhai Hospital Affiliated to Guangdong Provincial Traditional Chinese Medicine Hospital, Guangdong Province, Zhuhai 519015, China 　　[Abstract] Objective To investigate the value of ultrasound in detecting vascular endothelial function of diabetic with paroxysmal atrial fibrillation patients. Methods Diabetic patients with paroxysmal atrial fibrillation of 160 cases (observation group) and 160 healthy volunteers (control group) were used brachial artery ultrasound to assess their function. Results Compared with the control group, the FMD were significantly decreased in the observation group (P 0.05), left atrial volume had significantly increased (P 0.05.) The brachial artery diameter at baseline of the observation group was significantly greater than that of the control group (P 0.05). Conclusion The early non-invasive ultrasound technology evaluation diabetic endothelial function in patients with paroxysmal atrial fibrillation have broad clinical application for guiding the clinical application of improved early treatment and can reduce paroxysmal atrial fibrillation mortality. 　　[Key words] Diabetes; Paroxysmal atrial fibrillation; Ultrasound 　　 　　心房颤动（房颤）是脑血管疾病、心功能障碍和致死的重要危险因素，随着我国人口的老龄化，其发病率越来越高，多表现为阵发性房颤[1]。糖尿病是阵发性房颤的主要危险因素，有研究发现，糖尿病患者的阵发性房颤发病率较高[2]。流行病学研究显示糖尿病使阵发性房颤的危险增加2.3倍。近年来随着对阵发性房颤的生理及病理研究的深入，发现阵发性房颤患者存在心脏内皮细胞功能障碍，后者在阵发性房颤的发展及预后中起重要作用[3]。已有研究关于应用超声评估糖尿病合并阵发性房颤患者血管的心脏功能