超声造影诊断颈部浅表恶性肿大淋巴结临床研究.docVIP

超声造影诊断颈部浅表恶性肿大淋巴结临床研究 　　【摘要】 目的：探讨超声造影（CEUS）对颈部浅表恶性肿大淋巴结的诊断价值。方法：回顾性分析2014年9月-2015年12月本院48例颈部肿大淋巴结患者资料，所有患者均行常规超声、超声造影和病理活检。根据病理结果分为良性组（n=27）和恶性组（n=21）。两组性别、年龄、淋巴结直径比较均无显著统计学差异（P0.05）。结果：超声造影诊断符合率高于常规超声[91.67%（44/48）vs 77.08%（37/48）]，差异有统计学意义（P=0.049）。超声造影和常规超声ROC曲线下面积分别为0.907[95%CI（0.824，0.989）]和0.771[95%CI（0.652，0.889）]。平行试验敏感度和特异度为98.9%和64.6%，约登指数为0.64；序列试验敏感度和特异度为75.4%和96.7%，约登指数为0.72。结论：常规超声联合超声造影对颈部浅表恶性淋巴结肿大的诊断效能优于常规超声，序列试验可以提高诊断试验的特异度。 　　【关键词】 超声造影； 恶性； 肿大淋巴结； 浅表 　　Clinical Research of Contrast-enhanced Ultrasonography in Diagnosis of Superficial Cervical Malignant Lymphadenopathy/LI Xia，XIE Yu-huan，KUANG Yong-pei，et al.//Medical Innovation of China，2016，13（35）：035-038 　　【Abstract】 Objective：To investigate the diagnostic value of contrast-enhanced ultrasonography（CEUS） in superficial cervical malignant lymphadenopathy.Method：Forty-eight patients with cervical lymphadenopathy were enrolled into study from September 2014 to December 2015.Patients were detected by conventional，contrast-enhanced ultrasonography and pathological biopsy.According to pathology，forty-eight patients were divided into benign group（n=27） and malignant group（n=21）.There were no significant differences in gender，age，diameter of lymph nodes，primary diseases between two groups（P0.05）.Result：Diagnostic coincidence rate of contrast-enhanced ultrasonography was significantly higher than that of conventional ultrasound[91.67%（44/48）vs 77.08%（37/48），P=0.049].AUROC of contrast-enhanced ultrasound and conventional ultrasound were 0.907[95%CI（0.824，0.989）]，0.771[95%CI（0.652，0.889）].Serial test （sensitivity：75.4%，specificity：96.7%，Yuden Index：0.72） was superior to parallel test（sensitivity：98.9%，specificity：64.6%，Yuden Index：0.64）. Conclusion： Conventional ultrasonic combined contrast-enhanced ultrasonography（CEUS） is superior to conventional ultrasonography in diagnosis of neck superficial malignant lymphadenopathy.Serial test could improve specificity of diagnostic test. 　　【Key words】 Contra