阿司匹林预处理对多囊卵巢综合征行IVF―ET疗效及其机制研究.docVIP

阿司匹林预处理对多囊卵巢综合征行IVF―ET疗效及其机制研究 　　【摘要】 目的：探?阿司匹林预处理对多囊卵巢综合征行试管婴儿（invitro fertilization-embryo transfer，IVF-ET）的疗效及其机制。方法：选取2015年1月-2016年6月在珠海市妇幼保健院生殖中心因多囊卵巢综合征行试管婴儿治疗的患者119例，采用随机数字表法将患者分为研究组（62例）和对照组（57例）。研究组在IVF-ET治疗前给予阿司匹林预处理，对照组给予安慰剂治疗。观察比较两组患者的促性腺激素（Gn）使用时间、Gn使用剂量、获卵数、2PN受精率、优质胚胎数、启动日T淋巴细胞、肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）及IVF-ET结局。结果：研究组患者的Gn使用时间短于对照组，Gn使用剂量低于对照组，获卵数和优质胚胎数均高于对照组，差异均有统计学意义（P0.05）。结论：阿司匹林预处理对多囊卵巢综合征行IVF-ET有积极的临床意义。 　　【关键词】 阿司匹林； 多囊卵巢综合征； IVF-ET； T淋巴细胞； 肿瘤坏死因子-α； 白介素-6 　　Study on the Effect and Mechanism of Aspirin Pretreatment on IVF-ET in Patients with Polycystic Ovary Syndrome/XIONG Yong-lao，YANG Gui-yan，YANG Chang-yu，et al.//Medical Innovation of China，2017，14（15）：016-019 　　【Abstract】 Objective：To investigate the effect and mechanism of Aspirin pretreatment on invitro fertilization-embryo transfer （IVF-ET） in polycystic ovary syndrome（PCOS）.Method：From January 2015 to June 2016，in the reproductive center of Maternal and Child Health Care Hospital of Zhuhai，119 patients with polycystic ovary syndrome were treated with IVF-ET and selected，they were divided into research group （62 cases）and control group（57 cases） according to the random number table method.The research group was given Aspirin before IVF-ET treatment，the control group was given placebo.The Gonadotropin（Gn） using time，Gn using dosage，amount of acquired oocytes，high-quality embryos，level of the serum T lymphocytes，TNF-α and IL-6 at the initiation day and clinical results of the two groups were observed and compared.Result：The Gn using time of the research group was shorter than that of the control group，and the dosage of Gn was lower than that of the control group， the amount of the acquired oocytes and high-quality embryos of the research group were all more than those of the control group，the differences were statistically significant（P0.05）.Conclusion：Aspirin pretreatment has positive clinical significance in the treatment of polycystic ovary syndrome with IVF-ET. 　　【Key words】 A