预防性宫体注射卡前列素氨丁三醇防治高危产妇剖宫产术中出血有效性与安全性分析.docVIP

预防性宫体注射卡前列素氨丁三醇防治高危产妇剖宫产术中出血有效性与安全性分析 　　【摘要】 目的 探讨预防性宫体注射卡前列素氨丁三醇防治高危产妇剖宫产术中出血的有效性与安全性。方法 88例剖宫产高危产妇， 按照随机数字表法分为对照组和观察组， 各44例。对照组采用米索前列醇进行治疗， 观察组采用卡前列素氨丁三醇进行治疗， 比较两组术后出血量、产后出血发生情况、止血时间、子宫切除情况和不良反应发生情况。结果 观察组产妇产后2 h出血量为（219.3±61.9）ml， 　　产后24 h出血为（322.6±71.1）ml， 均少于对照组的（368.6±63.6）、（459.7±86.6）ml， 差异有统计学意义（Plt;0.05）。观察组产后出血率低于对照组， 止血时间短于对照组， 差异有统计学意义（Plt;0.05）;两组子宫切除率比较差异无统计学意义（Pgt;0.05）。两组不良反应发生率比较差异无统计学意义（Pgt;0.05）。 　　结论 预防性宫体注射卡前列素氨丁三醇防治高危产妇剖宫产术中出血的效果显著， 值得在临床上推广应用。 　　【关键词】 高危产妇;剖宫产;卡前列素氨丁三醇;产后出血 　　DOI：10.14163/j.cnki.11-5547/r.2018.07.050 　　【Abstract】 Objective To discuss the effectiveness and safety of proprophylactic intrauterine injection of romethamine to prevent bleeding during cesarean section of high-risk puerpera. Methods A total of 88 high-risk 　　puerpera were divided by random number table method into control group and observation group， with 44 cases in each group. The control group was treated with misoprostol， and the observation group was treated with romethamine. Comparison were made on postoperative bleeding， occurrence of postpartum hemorrhage， hemostasis time， hysterectomy and adverse reactions condition between the two groups. Results The observation group had postpartum 2 h hemorrhage as （219.3±61.9） ml， postpartum 24 h hemorrhage as （322.6±71.1） ml， which were all less than （368.6±63.6） and （459.7±86.6） ml in the control group， and their difference was statistically significant （Plt;0.05）. The observation group had lower postpartum hemorrhage and shorter hemostasis time than the control group， and their difference was statistically significant （Plt;0.05）. Both groups had no statistically significant difference in hysterectomy rate （Pgt;0.05）. Both groups had no statistically significant difference in incidence of adverse reactions （Pgt;0.05）. Conclusion Proprophylactic intrauterine injection of romethamine shows remarkable effect in preventing bleeding during cesarean section of high-risk puerpera， and it is worthy of clinical promotio