麝香保心丸联合阿司匹林对冠心病心绞痛患者体内炎性反应作用分析.docVIP

麝香保心丸联合阿司匹林对冠心病心绞痛患者体内炎性反应作用分析 　　【摘要】 目的：研究观察麝香保心丸联合阿司匹林对冠心病心绞痛患者体内炎性反应的应用效果。方法：选取本院收治的200例冠心病心绞痛患者，按随机数字表法均分为对照组和试验组。对照组给予阿司匹林片口服，0.15 g/次，1次/d。试验组在对照组基础上联合麝香保心丸口服，50 mg/次，3次/d。两组疗程均为60 d。观察比较两组治疗前后的IL-6、TNF-α与CRP水平的变化。结果：治疗前两组炎性指标比较差异无统计学意义（P0.05）。治疗后治疗组血清IL-6、TNF-α与CRP的水平较对照组均有明显降低，两组上述指标比较差异有统计学意义（P0.05）。结论：麝香保心丸联合阿司匹林，能有效控制冠心病心绞痛患者体内炎性反应，缓解心绞痛症状，效果优于单用阿司匹林，值得临床广泛推广使用。 　　【关键词】 麝香保心丸； 阿司匹林； 冠心病心绞痛； 炎性反应 　　The Effect of Shexiangbaoxin Pill Combined with Aspirin on the Inflammatory Response for Patients with Angina Pectoris/WU Zhi-shan，XU Xiao-qin.//Medical Innovation of China，2013，10（35）：154-155 　　【Abstract】 Objective：To study the effect of Shexiangbaoxin Pill Combined with aspirin for the inflammatory response in patients with angina pectoris.Method：200 cases in our hospital with angina were randomly divided into the control group and the experimental group according to random number table method.Control group was given aspirin tablet， 0.15 g/times，1times/d.Experimental group was given Shexiangbaoxin Pill oral， 50 mg/time， 3 times/d on the basis of control group，a course of 60 d. Observed and compared IL-6， TNF-α and CRP level changes of the tho groups before and after treatment.Result：Before treatment， inflammatory markers had no significant difference （P0.05）.After treatment， the serum IL-6， TNF-α and CRP levels in the experimental group decreased more than the control group， control the inflammatory response was better than the control group. The difference was statistically significant（P0.05）.Conclusion：Shexiangbaoxin Pill combined with aspirin， can effectively control the inflammatory response in patients with angina pectoris， relieve angina symptoms. It’s worthy of clinical widely used. 　　【Key words】 Shexiangbaoxin Pill； Aspirin； Angina Pectoris； Inflammatory Response 　　First-author’s address：Nanhai District Guicheng Hospital of Foshan City，Foshan 528200，China 　　doi：10.3969/j.issn.1674-4985.2013.35.074 　　冠心病心绞痛在中医学属于“胸痹、真心痛”的范畴。多因为脂质代谢异常及堆积，导致冠状动脉粥