黄体酮疗法对先兆流产患者妊娠期合并症及围生儿结局影响.docVIP

黄体酮疗法对先兆流产患者妊娠期合并症及围生儿结局影响 　　【摘要】 目的 分析对先兆流产患者应用黄体酮疗法对妊娠期合并症及围生儿结局的影响。 　　方法 选取早期先兆流产患者53例作为研究组， 另选取同期产检健康妊娠女性50例作为对照组。对照组给予口服叶酸、维生素E等常规孕期干预；研究组在对照组基础上应用黄体酮治疗。比较两组妊娠期合并症发生情况及围生儿结局。结果 两组胎盘前置、胎盘早剥、胎膜早破、妊娠期高血压、妊娠期糖尿病及妊娠期胆汁淤积的发生率比较差异无统计学意义（χ2=0.286、0.953、1.525、0.286、0.097、0.590， P0.05）。两组难免流产、早产、低体质量儿、巨大儿、胎儿窘迫、胎儿畸形、1 min Apgar评分≤7分发生率比较差异无统计学意义（χ2=0.953、0.424、0.286、0.924、0.154、0.286、0.286， P0.05）。结论 对先兆流产患者应用黄体酮疗法可降低妊娠期合并症的发生风险， 改善围生儿结局， 具有临床推广价值。 　　【关键词】 先兆流产；黄体酮疗法；妊娠期合并症；围生儿结局 　　DOI：10.14163/j.cnki.11-5547/r.2018.08.050 　　Effect of progesterone therapy on pregnancy complications and perinatal outcomes in patients with threatened abortion SUN Juan， MA Qing-hua. Rushan People’s Hospital， Rushan 264500， China 　　【Abstract】 Objective To analyze the effect of progesterone therapy on pregnancy complications and perinatal outcomes in patients with threatened abortion. Methods There were 53 patients with threatened abortion as research group， and another concurrent 50 female healthy pregnant women as the control group. The control group received conventional pregnancy intervention of oral folic acid， vitamin E， and the research group received progesterone therapy on the basis of the control group. Comparison were made on occurrence of pregnancy complications and perinatal outcomes between the two groups. Results Both groups had no statistically significant difference in incidence of placenta previa， placental abruption， premature rupture of membranes， gestational hypertension， gestational diabetes mellitus and pregnancy cholestasis （χ2=0.286， 0.953， 1.525， 0.286， 0.097， 0.590， P0.05）. Both groups had no statistically significant difference in incidence of inevitable miscarriage， premature birth， low body mass， huge children， fetal distress， fetal malformations， 1 min Apgar score ≤ 7 points （χ2=0.953， 0.424， 0.286， 0.924， 0.154， 0.286， 0.286， P0.05）. Conclusion Application of progesterone therapy for patients with threatened abortion can reduce the risk of pregnancy compl