鼻内翻性乳头状瘤影像学与组织Survivin表达研究.docVIP

鼻内翻性乳头状瘤影像学与组织Survivin表达研究 　　摘 要：目的 探讨鼻内翻性乳头状瘤(nasal inverted papilloma，NIP)的影像学特征以及细胞凋亡抑制蛋白 Survivin在NIP组织中的表达及其意义。方法 对11例NIP患者，术前采用CT和MRI平扫和增强的影像学检查，术中获取肿瘤组织标本，术后采用免疫组化Envision二步法检测组织标本中的 Survivin的表达，11例慢性鼻炎患者下鼻甲黏膜组织作对照。结果 单纯CT扫描可清楚显示NIP的范围以及和鼻腔鼻窦的关系，辅助MRI能提供NIP和黏膜炎症及潴留分泌物的差异，且能区别肿瘤与周围软组织的关系；Survivin在NIP组织的表达率为72.7%（8/11），显著高于慢性鼻炎下鼻甲黏膜组织的表达率0%（0/11），两者之间存在显著的统计学差异(P0.01)。 结论 CT平扫和增强以及三维重建是NIP首选，若需清晰显示NIP的范围及其与周围软组织的界线时建议增加MRI检查。Survivin作为细胞凋亡抑制蛋白可能在NIP的发生和发展过程中起着重要的促进作用。 　　关键词：鼻肿瘤；乳头状瘤；体层摄影术，X线计算机；磁共振成像；Survivin 　　Study on the imaging and Survivin expression in the tissues of nasal inverted papilloma 　　Abstract： Objective: To investigate the imaging features of nasal inverted papilloma (NIP) and the expression of inhibitor of apoptosis protein Survivin in NIP tissues and its significance. Methods: 11 patients with NIP were performed imaging examination with plain and enhanced CT and MRI preoperatively, and tumor tissue specimens were obtained during operation, and after operation, the expressions of Survivin in tissue specimens were detected with immunohistochemical Envision method, while nasal turbinate mucosa tissues of 11 patients with chronic rhinitis were selected as control. Results: Plain CT scan could clearly show the range of NIP and the relationship with nasal cavity and paranasal sinuses, which assisted MRI to provide the differences of NIP and mucosal inflammation and retention secretions, which could distinct the relationship between tumor and surrounding soft tissues; the expression rate of Survivin in the NIP tissues was 72.7% (8/11), which was significantly higher than the tissue expression rate of 0% in inferior turbinate mucosa of chronic rhinitis (0/11), existing statistically significant difference (P0.01). Conclusion: Plain and enhanced CT and 3D reconstruction is preferred for NIP, and if clear range of NIP and the boundaries with around soft tissues are needed, MRI examination is suggested to be added. As an inhibitor of apoptosis prote