黄芪对伴糖尿病精神分裂症患者抗氧化活性及胰岛素抵抗影响.docVIP

黄芪对伴糖尿病精神分裂症患者抗氧化活性及胰岛素抵抗影响 　　DOI：10.16658/j.cnki.1672-4062.2017.05.001 　　[摘要] 目的 探讨黄芪对伴糖尿病的精神分裂症患者抗氧化活性及胰岛素抵抗的影响。 方法 选择84例经过规则饮食控制后仍需降糖药物治疗的共患糖尿病的精神分裂症患者，给予胰岛素控制血糖稳定。随机分为研究组（41例）和对照组（43例）。在原有抗精神病药物治疗的基础上，研究组接受胰岛素联合黄芪治疗，对照组只接受胰岛素治疗。于治疗前及治疗后第8周分别测定两组患者血液超氧化物歧化酶（SOD）的活性、脂质过氧化物（LPO）的水解产物丙二醛（MDA）的含量及血糖、胰岛素、脂联素（APN）等。 结果 与对照组相比，研究组患者血清SOD、APN明显上升，而MDA明显下降。 结论 黄芪可有效提高机体的抗氧化能力，升高脂联素水平，改善机体功能，在伴糖尿病的精神分裂症患者及其并发症的治疗中起一定作用。 　　[关键词] 精神分裂症；糖尿病；黄芪；超氧化物歧化酶；脂质过氧化物；胰岛素抵抗 　　[中图分类号] R285.6 [文献标识码] A [文章编号] 1672-4062（2017）03（a）-0001-03 　　Effect of Astragalus Membranaceus on the Antioxidant Activity and Insulin Resistance of Patients with Schizophrenia with Diabetes 　　CHEN Ming-you 　　Department of Psychiatry， Yinan County Mental Rehabilitation Hospital， Yinan， Shandong Province， 276300 China 　　[Abstract] Objective To study the effect of astragalus membranaceus on the antioxidant activity and insulin resistance of patients with schizophrenia with diabetes. Methods 84 cases of schizophrenia and diabetes patients still needing the hypoglycemic agent treatment after the regular dieting control were selected and were given the insulin for controlling the steady blood glucose， and the patients were randomly divided into the research group with 41 cases and the control group with 43 cases， and the research group were treated with insulin and astragalus membranaceus on the basis of the primary antipsychotics， while the control group were only treated with insulin， and the SOD activity， MDA content of LPO， blood glucose， insulin and APN of the two groups were respectively measured before treatment and eight weeks after treatment. Results The serum SOD and APN in the research group were obviously increased compared with those in the control group， but the MDA obviously decreased. Conclusion Astragalus membranaceus can effectively improve the oxidation resistance of organs， increase the adiponectin level and improve the organ function， which has a certain effect on the treatment of patien