597例非淋菌性尿道炎患者支原体感染情况和耐药性分析.docVIP

597例非淋菌性尿道炎患者支原体感染情况和耐药性分析 　　[摘要] 目的：分析我院皮肤科2007年1月～2009年12月非淋菌性尿道炎（NGU）患者支原体感染及耐药性变迁情况，为临床提供最新的流行病学资料及用药指导。方法：应用板条培养药敏试剂法对解脲支原体（Uu）和人型支原体（Mh）进行检测和其对11种抗菌药物的药敏试验结果分析。结果：3年共检测临床拟诊为NGU的患者1 557例，支原体感染总阳性例数597例，阳性率为38.34%。其中解脲支原体（Ureaplasma urealyticum，Uu）、人型支原体（Mycoplasmahominis，Mh）、混合型（Mh+Uu）检出率分别为78.39%、3.69%、17.92%。女性阳性率为51.71%，男性阳性率为28.96%，女性感染率显著高于男性（χ2=82.609，P＜0.01）。随年份增加支原体阳性率有逐年增高的趋势，但各年度间差异无统计学意义（P＞0.05）。耐药检测结果表明，支原体对交沙霉素、美满霉素、强力霉素敏感率高（分别为99.16%，98.32%，97.65%），对环丙沙星的敏感率最低（14.07%）。结论：非淋菌性尿道炎支原体感染主要以Uu发病率最高，且在益阳地区女性检出率高于男性，临床对支原体感染治疗应根据药敏结果合理使用抗生素，以减少耐药菌株产生。 　　[关键词] 非淋菌性尿道炎；支原体；耐药性 　　[中图分类号] R695[文献标识码] C [文章编号] 1673-7210（2010）10（c）-121-03 　　 　　Infection status and drug susceptilibity analysis of Mycoplasma strains in 597 patients with non-gonoeeoeal urethritis 　　LI Yuejun, ZENG Jiangao 　　(Yiyang Central Hospital, Hunan Province, Yiyang413000, China) 　　[Abstract] Objective: To analyze Mycoplasma infection in non-gonoeeoeal urethritis(NGU)and the changes in drug resistance from January 2007 to December 2009, to provide the data of epidemiology and instruct rational application of antibiotics. Methods: Ureaplasma urealyticum (Uu) and Mycoplasma hominis (Mh) were detected with lath culture sensitivity reagent method and drug susceptibility test results were analyzed with 11 kinds of antimicrobial agents. Results: In 1 557 NGU patients, the total positive patients drug resistance by Mycoplasma was 597, the positive rate of Mycoplasma was 38.34%, and the positive rate of Ureaplasma urealyticum (Uu), Mycoplasma homonis (Mh), Uu and Mh were 78.39%,3.69%, 17.92%. The positive rate in female and male were 51.71% and 28.96%, respectively. The infection rate of female was obviously higher than that of male(χ2=82.609, P＜0.01). The postive rate heighten as well as the increased year, but there was no obviously difference in each year (P＞0.05). The susceptibility test indicated that the drug resistant rate of Mycoplasmas to josamycin, deoxycyline and minoccyline was