N―末端脑钠肽前体和社区获得性肺炎患者严重程度关系研究.docVIP

N―末端脑钠肽前体和社区获得性肺炎患者严重程度关系研究 　　摘 要：目的 探讨血清N-末端脑钠肽前体浓度与社区获得性肺炎的严重程度的关系。方法 对2016年11月～2017年4月于我院呼吸科住院的46例CAP 患者评估临床变量和肺炎严重指数，按照 PSI评分分组，比较各组血清NT-proBNP浓度，评价其与CAP严重程度关系。结果 NT-proBNP与PSI评分、Spearman相关（r=0.654，P0.05）；NT-proBNP与年龄Spearman相关（r=0.530，P0.05）；NT-proBNP与呼吸频率Spearman相关（r=0.382，P0.05），且各组NT-proBNP浓度随PSI分级升高而升高。NT-proBNP浓度与CAP病情严重程度呈正相关（r=0.654，P0.05）。结论 NT-proBNP与PSI评分呈显著正相关，其可以作为评估CAP患者病情严重程度的有效指标，但本研究样本量较少，结果可能存在一定的局限性，以及NT-proBNP水平与感染病原体是否相关还需进一步研究。 　　关键词：社区获得性肺炎；NT-proBNP；PSI评分 　　中图分类号：R563.1 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.04.001 　　文章编号：1006-1959（2018）04-0001-03 　　Abstract：Objective To investigate the relationship between the concentration of serum N-terminal brain natriuretic peptide（NTP）and the severity of community-acquired pneumonia（CPAP）.Methods The clinical variables and the severity index of pneumonia were evaluated in 46 CAP patients hospitalized in respiratory department from November 2016 to April 2017.According to the PSI score，the serum NT-proBNP concentration was compared.Evaluate its relationship with CAP severity.Results NT-proBNP and PSI were correlated with Spearman score （r=0.654，P0.05）；NT-proBNP was associated with Spearman age（r=0.530，P0.05）.NT-proBNP was correlated with respiratory frequency Spearman（r=0.382，P0.05），the concentration of NT-proBNP in each group increased with the increase of PSI grade.The concentration of NT-proBNP was positively correlated with the severity of CAP（r=0.654，P0.05）.Conclusion There is a significant positive correlation between NT-proBNP and PSI score，which can be used as an effective index to evaluate the severity of CAP in patients with CAP.However，the sample size in this study is small，and the results may have some limitations，and whether NT-proBNP levels and pathogen infection related needs further study. 　　Key words：Community-acquired pneumonia；NT-proBNP；PSI score 　　社?^获得性肺炎（community-acquired pneumonia，CAP）是最常见的一种感染性疾病，已经成为全世界范围内较为严重的医疗问题[1]，并且随着年龄增长其发病率及死亡率逐渐升高。N-末端脑钠肽前体（NT-proBNP）由心室肌细