丙戊酸钠联合奎硫平和氟哌啶醇治疗躁狂发作疗效对照研究.docVIP

丙戊酸钠联合奎硫平和氟哌啶醇治疗躁狂发作疗效对照研究 　　【摘要】 目的 比较丙戊酸钠联合奎硫平与联合氟哌啶醇治疗急性躁狂发作的疗效及安全性。方法 将68例急性躁狂发作患者随机分为两组，奎硫平组34例，氟哌啶醇组34例，两组分别在应用丙戊酸钠治疗的基础上联合用奎硫平或氟哌啶醇治疗，疗程均为6周；采用躁狂量表及副作用量表评定临床疗效和不良反应。结果 治疗第6周末，奎硫平组显效率为73.52%，氟哌啶醇组为75.76%，两组总体疗效相当；奎硫平组不良反应明显少于氟哌啶醇组(P0.05)。结论 丙戊酸钠联合奎硫平与联合氟哌啶醇治疗急性躁狂发作疗效相当，但副反应少、安全性高。 　　【关键词】 躁狂发作；奎硫平；氟哌啶醇；丙戊酸钠 　　 　　A Control Study of Sodium Valproate Combined with Quetiapine or Haloperidol in the Treatment of Manic Episode. Liu Xiaohua, Lv Wei, Li Meihua, et al. Tianjin Anding Hospital, Tianjin 300074, P.R.China 　　【Abstract】 Objective To compare the efficacy and safety of sodium valproate combined with quetiapine or haloperidol in the treatment of manic episode. Methods The 68 patients in accordance with the criteria of Manic episode or Recurrent mania or Bipolar disorder, current episode manic in CCMD-3 were randomly assigned to two groups: quetiapine group (34 patients) treated by quetiapine with sodium valproate and haloperidol group (34 patinents) treated by haloperidol with sodium valproate for 6 weeks. The Beck-Rafaelsen Manic Scale (BRMS) and TESS were individually used to assess efficacy and safety．Results After 6 weeks treatment, the tota1 effective rates were 73.52% in quetiapine group and 75.76% in haloperidol group and the gross curative effects in two group were equivalent. But the side effects in quetiapine group were significantly fewer than that in quetiapine group. Conclusion The effects of sodium valproate combined with quetiapine were equivalent to sodium valproate combined with haloperidol in the treatment of manic episode; but the side effects were fewer in sodium valproate combined with quetiapine treatment. 　　【Key words】 Manic episode; Quetiapine; Haloperidol; Sodium valproate 　　 　　心境稳定剂联合抗精神病药治疗躁狂发作是临床治疗中常用的方案[1,2]。作者对丙戊酸钠联合奎硫平与联合氟哌啶醇在治疗急性躁狂发作中的临床疗效及安全性进行了对照观察，现将结果报告如下。 　　 　　1 对象与方法 　　 　　1.1 对象 选取2004年12月～2005年12月在许昌市建安医院住院的躁狂发作患者为研究对象。入组标准为：①符合《中国精神障碍分类与诊断标准》第3版(CCMD-3)单次躁狂发作、反复躁狂发作及双相障碍躁狂相诊断标准；②年龄l8～59岁；③躁狂量表(BMRS)评分总分≥22分；④