卵巢癌临床分析和临床治疗新进展.docVIP

卵巢癌临床分析和临床治疗新进展 　　【摘要】目的：分析卵巢癌的治疗过程与经验，探讨卵巢癌病理因素对生存时间的影响。方法：回顾性分析患者治疗全过程的临床资料，整理分析卵巢癌患者病理分型的基本情况，对治疗前CEA、AFP、CA125等血清肿瘤标记物测定结果分析，并运用COX回归模型多因素分析卵巢癌患者临床病理因素与生存时间的关系。所有患者均接受手术联合化疗进行治疗。结果：3例Ⅰa期患者单纯附件切除，术后化疗6次，至今未复发；13例Ⅰ期及8例Ⅱ期患者手术后化疗至今3年未复发，另外5例Ⅰ期至今1年未复发；治疗后Ⅲ期和Ⅳ期患者中共有9例死亡，其余21例至今2年未见复发，剩余5例患者仍在治疗。术前CA125水平，术后患者满意度，术后辅助化疗以及肿瘤类型与患者的生存时间差异均不存在统计学意义（P0.05）。结论：卵巢癌病理类型复杂，早期治疗效果较好。 　　【关键词】卵巢癌；临床分析???靶向治疗；新进展 　　Objective： to analyze the treatment experience and ovarian cancer， to investigate the effect of ovarian cancer pathological factors on survival time. Methods： a retrospective analysis of clinical data of patients with the treatment procedure， the basic situation analysis of pathology in patients with ovarian cancer types， analysis of the results of determination of serum tumor before treatment CEA， AFP， CA125 markers， and the use of COX regression model analysis of ovarian cancer patients with clinical pathological factors and survival time. All patients underwent operation combined with chemotherapy for treatment. Results： 3 cases of stage I a patients with simple accessories resection， postoperative chemotherapy 6 times， so far without recurrence； 13 cases and 8 cases of stage II patients chemotherapy after operation since 3 years without recurrence， another 5 cases since 1 years without recurrence； treatment of stage III and IV patients with a total of 9 patients death， the remaining 21 cases to the present 2 years without recurrence， the remaining 5 patients remain in the treatment. The preoperative CA125 level， the satisfaction of patients after surgery， adjuvant chemotherapy and tumor types and the survival time of patients after surgery were not difference had statistical significance （P0.05）. Conclusion： pathological types of ovarian cancer is complex， early treatment effect is good. 　　Keywords： ovarian cancer； clinical analysis； targeted therapy； new progress 　　【中图分类号】R4 【文献标识码】A 【文章编号】1671-8801（2014）04-0012-02 　　卵巢癌在女性生殖器癌瘤中的发生率占第3 位， 是妇科恶性肿瘤病死率最高的[1]。卵巢