腹型肥胖患者血浆HsCRP水平和体重指数相关性研究.docVIP

腹型肥胖患者血浆HsCRP水平和体重指数相关性研究 　　[摘要] 目的 探讨腹型肥胖患者血浆Hs-CRP水平与体重指数的关系。方法 收集明确诊断为腹型肥胖患者116例，同时收集35例体重正常者作为对照组，两组人群均明确排除合并其他炎症反应如：上呼吸道感染、肺炎、腹泻、泌尿系感染等疾病。依据腹型肥胖患者体重指数(body mass index,BMI)四分位数将所有患者分为四组，比较各组间血浆Hs-CRP水平。采用Pearson相关分析血浆Hs-CRP水平与BMI关系。结果 (1)与对照组相比，腹型肥胖者BMI、高血压、高脂血症、2型糖尿病发病率以及血浆Hs-CRP水平均明显升高（P0.05），以此同时，腹型肥胖组患者，随着BMI的增大，其高血压、高脂血症、2型糖尿病发病率以及血浆Hs-CRP水也逐渐升高(P0.05)；(2)采用Pearson相关性分析提示，腹型肥胖者血浆Hs-CRP水平与其BMI呈正相关，相关系数r=0.904(P0.05)；以此同时，采用Spearman秩相关分析提示，血浆Hs-CRP水平与高血压、高脂血症、2型糖尿病发病率也呈正相关，相关系数分别为r1=0.846(P0.05)，r2=0.808(P0.05)和r3=0.855(P0.05)。结论 腹型肥胖患者随着BMI的增加，其血浆Hs-CRP水平也逐渐升高，且腹型肥胖患者血浆Hs-CRP水平与高血压、高脂血脂和2型糖尿病发病率呈正相关。检测腹型肥胖患者血浆Hs-CRP水平对评估患者心脑血管疾病风险具有一定的临床价值。 　　[关键词] 腹型肥胖； 高敏C-反应蛋白； 体重指数 　　[中图分类号] R446.11 [文献标识码] B [文章编号] 1005-0515（2012）-01-043-02 　　 　　Relationship Research of BMI with Serum level of Hs-CRP in Patients with Abdominal Obesity 　　Zhao Juquan Xie Bing Yuan Chengwei 　　(The Clinical Laboratory of Guicheng Hospital in Nanhai,Guangdong，Foshan,528200) 　　[Abstract] Objective To investigate the relationship of body mass index (BMI) with serum level of high sensitivity C-reactive protein (Hs-CRP) in patients with abdominal obesity. Methods 116 patients defined as abdominal obesity and 35 cases with normal body weight as control group were enrolled, both the subjects of the two groups were excluded with other inflammatory reaction such as upper respiratory infection, pneumonia, diarrhea, and urinary tract infection. Patients with abdominal obesity were assigned into four groups according to the quartile of BMI, and serum levels of Hs-CRP were compared among these groups. Relationship of BMI with serum level of Hs-CRP was evaluated with Pearson correlation analysis. Results (1)Compared to the control group, BMI, incidences of hypertension, hyperlipidemia and type 2 diabetes mellitus and serum level of Hs-CRP were significantly higher in patients with abdominal obesity（P0.05）,and the incidences of hypertension, hyperlipidemia and type 2 diabetes mellitus and serum l