头痛宁方治疗偏头痛临床的研究.docVIP

头痛宁方治疗偏头痛临床的研究 　　摘要：目的 观察头痛宁方治疗偏头痛的临床疗效。方法 将100例偏头痛风邪上扰、瘀血阻络证患者随机分为试验组和对照组各50例。试验组予头痛宁方口服，对照组予氟桂利嗪胶囊5 mg口服，疗程30 d。观察2组患者治疗前后偏头痛发作次数、程度、持续时间、伴随症状分值及总分，记录药物不良反应，评价临床疗效及安全性。结果 试验组总有效率为92.0%（46/50），对照组为64.0%（32/50）；不良反应发生率试验组为20.0%（10/50），对照组为80.0%（40/50）。2组疗效及不良反应比较差异均有统计学意义（P0.05）。2组治疗后偏头痛发作次数、持续时间及伴随症状分值比较差异均有统计学意义（P0.05）。各指标得分治疗前后差值组间比较差异有统计学意义（P0.05）。结论 头痛宁方能够明显改善风邪上扰、瘀血阻络证偏头痛患者的症状，且不良反应少，较氟桂利嗪更为安全有效。 　　关键词：头痛宁方；偏头痛；氟桂利嗪；临床研究 　　DOI：10.3969/j.issn.1005-5304.2016.04.004 　　中图分类号：R277.772 文献标识码：A 文章编号：1005-5304（2016）04-0012-04 　　Clinical Study on Toutongning Formula in Treatment of Migraine REN Shan， CHEN Zhi-gang （Dongfang Hospital， Beijing University of Chinese Medicine， Beijing 100078， China） 　　Abstract： Objective To observe the clinical efficacy of Toutongning Formula in the treatment of migraine. Methods Totally 100 cases of migraine patients （wind disturbance， blood stasis syndrome） were randomly divided into two groups. Patients in the experimental group were treated with Toutongning Formula orally， and patients in the control group were treated with flunarizine capsules 5 mg orally， for 30 d. The scores of number， degree， duration and accompanying symptoms of episodes before and after treatment were observed， the total scores were calculated， and adverse reactions were recorded， to evaluate the clinical efficacy and safety. Results Clinical total efficiency was 92.0% （46/50） in experimental group and 64.0% （32/50） in the control group； the incidence rate of adverse reactions was 20.0% （10/50） in experimental group and 80.0% （40/50） in the control group； there was statistical significant differences in efficacy and adverse reactions between the two groups （P0.05）. After the treatment， the differences in the scores of number， degree， duration and accompanying symptoms of episodes， and in the total scores between the two groups was statistically significant （P0.05）. There was statistical significance in the different value of above indexes before and after