多伦多病童医院脑干胶质瘤PPT幻灯片资料.pptVIP

Paediatric Brainstem Tumours;Brainstem Gliomas;Low grade glioma of the brainstem;Diagnosis and management of LGG;August 2001;August 2000;Diagnosis and management of LGG;;Diagnosis (11/2013);The diffuse intrinsic brainstem tumours;The diffuse intrinsic brainstem tumours;The diffuse intrinsic brainstem tumours;Typical DPG;Typical BSG ;The atypical brainstem tumours;13 year old 10 month history of progressive right sided weakness, (R) CN 7 and 8 Grade 2 on histolology ;17 year old 12 month history of dizziness when lying down No CN deficit, no Long tract sign, no ataxia;The atypical brainstem tumours;The atypical brainstem lesions;11 year-old;January 2004;Brainstem tumours in babies;1 day old PM: PNET;LGG of infancy;How to distinguish?;DPG;Focal HGG;2 ? year-old, 5 months history of ataxia and gaze palsy;3 years old, NF1;3 years old – Mild hemiparesis Biopsy: infiltrative astrocytoma (grade 2);MALIGNANT GLIOMA OF PONS CANADIAN CASES BY YEAR;Management of DIPG;Short symptoms ( 1 month) Classical triad Cranial nerve deficits Long tract signs Ataxia NO NEED FOR BIOPSY! TREATMENT SHOULD BE STARTED ASAP (within 48 hours);Management;Diffuse Pontine Glioma;Management;Hyperfractionation: results of prospective studies;Freeman et al, POG 9239, IJROBP1999;Management;Management;Hypofractionation;Hypofractionaltion ;Management;Diffuse brainstem GliomasRole of chemotherapy;Diffuse brainstem GliomasRole of chemotherapy;Diffuse brainstem GliomasRole of chemotherapy;Diffuse brainstem Gliomas:Other agents;Correlative studies;Diffuse brainstem GliomasResults;Examples;LONG TERM SURVIVORS;Age at Diagnosis (MONTHS);MRI IMAGING OF LONG TERM SURVIVORS;Are they true DIPG?;Are they true DIPG?;October 2011;Diffuse brainstem GliomasNorth American studies;Brainstem Gliomas;Brainstem Gliomas;Biospy for DIPG: Why? How?;How is it done?;Limitations;Necker series;Biopsy;Convection delivery (Lonser J Child Neurol 2008) ;Convective delivery;Convective delivery;Convective delivery;Dec 2013;DIPG