反复发生腹膜透析相关腹膜炎危险因素分析-内科学(肾脏病)专业论文.docxVIP

Risk Factors Analysis Of Multiple Peritoneal Dialysis Related Peritonitis Abstract Background and Purpose Peritoneal dialysis(PD)is one of renal replacement therapy for end-stage renal disease. Peritonitis is the ma in and most serious c omplications of P D. PD-related peritonitis will accelerate the loss of peritoneal function, decline of residual renal function in PD patients, and was the most common cause of technical failure and hospitalization[ HYPERLINK \l _bookmark0 1]. Related studies show that the technology survival rate was 93%, 73% and 63% after 1, 3, 5 years treatment, and the main reason leading to technical failure was peritonitis, accounting for about 78%[ HYPERLINK \l _bookmark1 2]. Patients with severe peritonitis can al so lead t o death d irectly. Research s hows, peritonitis associated with 92% o f deaths caused by infections in PD patients[ HYPERLINK \l _bookmark2 3]. T he rate of d eath caused by peritonitis directly was 1 to 6%[ HYPERLINK \l _bookmark3 4], and in 16% of PD patients death peritonitis is a direct participation factor[ HYPERLINK \l _bookmark4 5]. The r esearch have s hown t hat t he p eritonitis episode previous will c ontinuing and significantly a ffecting the risk of peritonitis even after 6 m onths[ HYPERLINK \l _bookmark5 6]. Multiple p eritonitis episodes will in evitably lead to p ersistent in flammation, s o that the adverse e ffects of a single event is a ccumulated, result in more s erious ad verse e ffects on t he p eritoneal function, residual renal function, nutrition and immune status, and accelerating technology failure and dropout of PD patients. The clinical data of our PD centre in recent seven years shows t hat, the r ate o f catheter removal was 6.35% in PD patients with single peritonitis Li, P.K., C.C. Szeto, B. Piraino, et al., Peritoneal dialysis-related infections recommendations: 2010 update. Perit Dial Int, 2010. 30(4): p. 393-423. Woodrow, G., J.H. Turney, and A.M. Brownjohn, Technique failure i